Evidence map›Paper›PMID 25166907›Full record

ArticlePLoS genetics2014

A cis-regulatory mutation of PDSS2 causes silky-feather in chickens.

Chungang Feng, Yu Gao, Ben Dorshorst, Chi Song, Xiaorong Gu, Qingyuan Li, Jinxiu Li, Tongxin Liu, Carl-Johan Rubin, Yiqiang Zhao and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
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  7. Review
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  10. Advances on genetic and genomic studies of ALV resistance.Journal of animal science and biotechnology · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Article
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  16. Review
  17. Article
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  19. Article
  20. Domestic animals as models for biomedical research.Upsala journal of medical sciences · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Chungang FengState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China; College of Animal Science and Technology, China Agricultural University, Beijing, China.
Yu GaoState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
Ben DorshorstScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden; Department of Animal and Poultry Sciences, Virginia Tech, Blacksburg, Virginia, United States of America.
Chi SongState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; Jiangsu Institute of Poultry Science, Yangzhou, Jiangsu, China.
Xiaorong GuState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China.
Qingyuan LiState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China.
Jinxiu LiState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China.
Tongxin LiuState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China.
Carl-Johan RubinScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Yiqiang ZhaoState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China.
Yanqiang WangState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China.
Jing FeiState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China.
Huifang LiJiangsu Institute of Poultry Science, Yangzhou, Jiangsu, China.
Kuanwei ChenJiangsu Institute of Poultry Science, Yangzhou, Jiangsu, China.
Hao QuInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong, China.
Dingming ShuInstitute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong, China.
Chris AshwellPrestage Department of Poultry Science, North Carolina State University, Raleigh, North Carolina, United States of America.
Yang DaDepartment of Animal Science, University of Minnesota, Saint Paul, Minnesota, United States of America.
Leif AnderssonScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Xiaoxiang HuState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China.
Ning LiState Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing, China; College of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Silky-feather has been selected and fixed in some breeds due to its unique appearance. This phenotype is caused by a single recessive gene (hookless, h). Here we map the silky-feather locus to chromosome 3 by linkage analysis and subsequently fine-map it to an 18.9 kb interval using the identical by descent (IBD) method. Further analysis reveals that a C to G transversion located upstream of the prenyl (decaprenyl) diphosphate synthase, subunit 2 (PDSS2) gene is causing silky-feather. All silky-feather birds are homozygous for the G allele. The silky-feather mutation significantly decreases the expression of PDSS2 during feather development in vivo. Consistent with the regulatory effect, the C to G transversion is shown to remarkably reduce PDSS2 promoter activity in vitro. We report a new example of feather structure variation associated with a spontaneous mutation and provide new insight into the PDSS2 function.

Indexed as

Regulatory Sequences, Nucleic AcidAlkyl and Aryl TransferasesAnimalsBreedingChickensFeathersGene Expression Regulation, DevelopmentalGenetic LinkageMutationPhenotypePromoter Regions, GeneticAlkyl and Aryl Transferasesdecaprenyl pyrophosphate synthetase

Identifiers

PMID25166907
PMCPMC4148213

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.