ArticleNature methods2014
Improved reproducibility by assuring confidence in measurements in biomedical research.
Article in Nature methods, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Dimensional analysis as a tool for biofilm comparative analysis: bridging the interdisciplinary divides.Journal of bacteriology · 2026Review
- Evolution of the PRNT: Merging tradition and innovation to set the gold standard in the era of automation.Human vaccines & immunotherapeutics · 2025Review
- Article
- Evaluation of image analysis tools for the measurement of cellular morphology.Frontiers in cell and developmental biology · 2025Review
- Bioengineering breakthroughs: The impact of stem cell models on advanced therapy medicinal product development.World journal of stem cells · 2024Review
- Mechanism of action, potency and efficacy: considerations for cell therapies.Journal of translational medicine · 2024Review
- Variability and bias in microbiome metagenomic sequencing: an interlaboratory study comparing experimental protocols.Scientific reports · 2024Article
- Review
- An SI-traceable reference material for virus-like particles.iScience · 2022Article
- Measuring Protein Aggregation and Stability Using High-Throughput Biophysical Approaches.Frontiers in molecular biosciences · 2022Article
- Standardization of luminescence, fluorescence measurements, and light microscopy: Current situation and perspectives.Biophysics and physicobiology · 2022Article
- The NIH Somatic Cell Genome Editing program.Nature · 2021Review
- Interpreting SARS-CoV-2 seroprevalence, deaths, and fatality rate - Making a case for standardized reporting to improve communication.Mathematical biosciences · 2021Review
- Analysis and uncertainty quantification of DNA fluorescence melt data: Applications of affine transformations.Analytical biochemistry · 2020Article
- How to measure and evaluate binding affinities.eLife · 2020Article
- Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar!Pharmaceutics · 2020Review
- Antibody validation for Western blot: By the user, for the user.The Journal of biological chemistry · 2020Article
- Nanoparticle administration method in cell culture alters particle-cell interaction.Scientific reports · 2019Article
- Strategies for robust and accurate experimental approaches to quantify nanomaterial bioaccumulation across a broad range of organisms.Environmental science. Nano · 2019Article
- Reproducibility of sublingual microcirculation parameters obtained from sidestream darkfield imaging.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
‘Irreproducibility’ is symptomatic of a broader challenge in measurement in biomedical research. From the US National Institute of Standards and Technology (NIST) perspective of rigorous metrology, reproducibility is only one aspect of establishing confidence in measurements. Appropriate controls, reference materials, statistics and informatics are required for a robust measurement process. Research is required to establish these tools for biological measurements, which will lead to greater confidence in research results.
Indexed as
Identifiers
25166868What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.