ArticlePloS one2014
Balanced trade-offs between alternative strategies shape the response of C. elegans reproduction to chronic heat stress.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 42 citations in OpenAlex.
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- An mTORC2-Lipid Signaling Axis Controls Stress-Induced Organismal Death.Research square · 2026Article
- Distinct requirements for the C. elegans Delta ligand APX-1 in embryonic viability and adult fertility.G3 (Bethesda, Md.) · 2025Article
- The mex-3 3' untranslated region is essential for reproduction during temperature stress.Development (Cambridge, England) · 2025Article
- Reproductive Costs Increase With Longer Extreme Heat Events in Collembola.Ecology and evolution · 2025Article
- Thermosensory behaviors of the free-living life stages of Strongyloides species support parasitism in tropical environments.PLoS neglected tropical diseases · 2024Article
- Thermosensory behaviors of the free-living life stages ofbioRxiv : the preprint server for biology · 2024Article
- TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.Nucleic acids research · 2023Article
- Review
- Serotonergic signaling plays a deeply conserved role in improving oocyte quality.Developmental biology · 2023Article
- TDP-1 and FUST-1 co-inhibit exon inclusion and control fertility together with transcriptional regulation.bioRxiv : the preprint server for biology · 2023Article
- Sex-specificity of the C. elegans metabolome.Nature communications · 2023Article
- A male pheromone that improves the quality of the oogenic germline.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Reproductive consequences of transient pathogen exposure across host genotypes and generations.Ecology and evolution · 2022Article
- The Physiological and Evolutionary Ecology of Sperm Thermal Performance.Frontiers in physiology · 2022Review
- Article
- Chronic temperature stress inhibits reproduction and disrupts endocytosis via chaperone titration in Caenorhabditis elegans.BMC biology · 2021Article
- Association with a novel protective microbe facilitates host adaptation to a stressful environment.Evolution letters · 2021Article
- Health and longevity studies in C. elegans: the "healthy worm database" reveals strengths, weaknesses and gaps of test compound-based studies.Biogerontology · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To ensure long-term reproductive success organisms have to cope with harsh environmental extremes. A reproductive strategy that simply maximizes offspring production is likely to be disadvantageous because it could lead to a catastrophic loss of fecundity under unfavorable conditions. To understand how an appropriate balance is achieved, we investigated reproductive performance of C. elegans under conditions of chronic heat stress. We found that following even prolonged exposure to temperatures at which none of the offspring survive, worms could recover and resume reproduction. The likelihood of producing viable offspring falls precipitously after exposure to temperatures greater than 28°C primarily due to sperm damage. Surprisingly, we found that worms that experienced higher temperatures can recover considerably better, provided they did not initiate ovulation. Therefore mechanisms controlling this process must play a crucial role in determining the probability of recovery. We show, however, that suppressing ovulation is only beneficial under relatively long stresses, whereas it is a disadvantageous strategy under shorter stresses of the same intensity. This is because the benefit of shutting down egg laying, and thus protecting the reproductive system, is negated by the cost associated with implementing this strategy--it takes considerable time to recover and produce offspring. We interpret these balanced trade-offs as a dynamic response of the C. elegans reproductive system to stress and an adaptation to life in variable and unpredictable conditions.
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