ArticlePLoS neglected tropical diseases2014
Co-evolution between an endosymbiont and its nematode host: Wolbachia asymmetric posterior localization and AP polarity establishment.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics.PLoS pathogens · 2025Article
- Maternal inheritance of functional centrioles in two parthenogenetic nematodes.Nature communications · 2024Article
- Inter-kingdom communication and the sympoietic way of life.Frontiers in cell and developmental biology · 2024Article
- A Light in the Dark: Uncovering Wolbachia-Host Interactions Using Fluorescence Imaging.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The cellular lives of Wolbachia.Nature reviews. Microbiology · 2023Review
- A highly divergentProceedings. Biological sciences · 2022Article
- Living in the endosymbiotic world of Wolbachia: A centennial review.Cell host & microbe · 2021Review
- Dual RNAseq analyses at soma and germline levels reveal evolutionary innovations in the elephantiasis-agent Brugia malayi, and adaptation of its Wolbachia endosymbionts.PLoS neglected tropical diseases · 2021Article
- Ongoing Coevolution ofMicroorganisms · 2020Article
- Bacteria- and temperature-regulated peptides modulate β-catenin signaling inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Wolbachia Symbiont: Here, There and Everywhere.Results and problems in cell differentiation · 2020Article
- We're in this Together: Sensation of the Host Cell Environment by Endosymbiotic Bacteria.Results and problems in cell differentiation · 2020Article
- Vertical transmission inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- TheMicrobiology spectrum · 2019Review
- From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.Genetics · 2018Review
- Article
- On the Reciprocally Causal and Constructive Nature of Developmental Plasticity and Robustness.Frontiers in genetics · 2018Review
- Article
- Comparative Genomics ofFrontiers in microbiology · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While bacterial symbionts influence a variety of host cellular responses throughout development, there are no documented instances in which symbionts influence early embryogenesis. Here we demonstrate that Wolbachia, an obligate endosymbiont of the parasitic filarial nematodes, is required for proper anterior-posterior polarity establishment in the filarial nematode B. malayi. Characterization of pre- and post-fertilization events in B. malayi reveals that, unlike C. elegans, the centrosomes are maternally derived and produce a cortical-based microtubule organizing center prior to fertilization. We establish that Wolbachia rely on these cortical microtubules and dynein to concentrate at the posterior cortex. Wolbachia also rely on PAR-1 and PAR-3 polarity cues for normal concentration at the posterior cortex. Finally, we demonstrate that Wolbachia depletion results in distinct anterior-posterior polarity defects. These results provide a striking example of endosymbiont-host co-evolution operating on the core initial developmental event of axis determination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.