ArticleBioMed research international2014
Nerve regenerative effects of GABA-B ligands in a model of neuropathic pain.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Evaluation of the Antihyperalgesic Potential ofCurrent issues in molecular biology · 2025Article
- Dynamic regulation ofFrontiers in cell and developmental biology · 2025Article
- Peripheral mechanisms of chronic pain.Medical review (2021) · 2022Review
- GABACurrent topics in behavioral neurosciences · 2022Review
- The Aging GABAergic System and Its Nutritional Support.Journal of nutrition and metabolism · 2021Review
- Genomic and Non-genomic Action of Neurosteroids in the Peripheral Nervous System.Frontiers in neuroscience · 2020Review
- Functional Recovery Occurs Even After Partial Remyelination of Axon-Meshed Median and Ulnar Nerves in Mice.Neurochemical research · 2019Article
- GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination.Molecular neurobiology · 2019Article
- M2 receptors activation modulates cell growth, migration and differentiation of rat Schwann-like adipose-derived stem cells.Cell death discovery · 2019Article
- Emerging Role of Schwann Cells in Neuropathic Pain: Receptors, Glial Mediators and Myelination.Frontiers in cellular neuroscience · 2019Review
- Schwann cell development, maturation and regeneration: a focus on classic and emerging intracellular signaling pathways.Neural regeneration research · 2017Review
- Blockade of transient receptor potential cation channel subfamily V member 1 promotes regeneration after sciatic nerve injury.Neural regeneration research · 2015Article
- Combination of GABA-derived short peptides and pregabalin in neuropathic pain: In vivo and in silico evaluation.Molecular painArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain arises as a direct consequence of a lesion or disease affecting the peripheral somatosensory system. It may be associated with allodynia and increased pain sensitivity. Few studies correlated neuropathic pain with nerve morphology and myelin proteins expression. Our aim was to test if neuropathic pain is related to nerve degeneration, speculating whether the modulation of peripheral GABA-B receptors may promote nerve regeneration and decrease neuropathic pain. We used the partial sciatic ligation- (PSL-) induced neuropathic model. The biochemical, morphological, and behavioural outcomes of sciatic nerve were analysed following GABA-B ligands treatments. Simultaneous 7-days coadministration of baclofen (10 mg/kg) and CGP56433 (3 mg/kg) alters tactile hypersensitivity. Concomitantly, specific changes of peripheral nerve morphology, nerve structure, and myelin proteins (P0 and PMP22) expression were observed. Nerve macrophage recruitment decreased and step coordination was improved. The PSL-induced changes in nociception correlate with altered nerve morphology and myelin protein expression. Peripheral synergic effects, via GABA-B receptor activation, promote nerve regeneration and likely ameliorate neuropathic pain.
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Registered trials
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