ArticleBioMed research international2014
Repair of segmental load-bearing bone defect by autologous mesenchymal stem cells and plasma-derived fibrin impregnated ceramic block results in early recovery of limb function.
Article in BioMed research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- High Molecular Weight Poly(glutamic acid) to Improve BMP2-Induced Osteogenic Differentiation.Molecular pharmaceutics · 2022Article
- Bone healing study of alendronate combined with enoxaparin sodium bone cement in rabbits with bone defects.Journal of orthopaedic surgery and research · 2022Article
- Scanning Probe Microscopy Bone Marrow Determination of Steogenic Differentiation of Mesenchymal Stem Cells.Contrast media & molecular imaging · 2022Article
- Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis.Journal of materials science. Materials in medicine · 2021Article
- Tissue mechanics in stem cell fate, development, and cancer.Developmental cell · 2021Review
- Prospect of Metal Ceramic (Titanium-Wollastonite) Composite as Permanent Bone Implants: A Narrative Review.Materials (Basel, Switzerland) · 2021Review
- Nanoclay Promotes Mouse Cranial Bone Regeneration Mainly through Modulating Drug Binding and Sustained Release.Applied materials today · 2020Article
- Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview.Journal of orthopaedic translation · 2020Review
- Peptide Self-Assembly into Hydrogels for Biomedical Applications Related to Hydroxyapatite.Gels (Basel, Switzerland) · 2019Review
- The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine.ACS biomaterials science & engineering · 2018Article
- Tissue Force Programs Cell Fate and Tumor Aggression.Cancer discovery · 2017Review
- Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation.Biomaterials · 2017Article
- Restoration of bone defects using modified heterogeneous deproteinized bone seeded with bone marrow mesenchymal stem cells.American journal of translational research · 2017Article
- Stem and progenitor cells: advancing bone tissue engineering.Drug delivery and translational research · 2016Review
- Application of platelet-rich plasma with stem cells in bone and periodontal tissue engineering.Bone research · 2016Review
- Ex Vivo Modeling of Multidomain Peptide Hydrogels with Intact Dental Pulp.Journal of dental research · 2015Article
- Microstereolithography-Based Fabrication of Anatomically Shaped Beta-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering.BioMed research international · 2015Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium phosphate-based bone substitutes have not been used to repair load-bearing bone defects due to their weak mechanical property. In this study, we reevaluated the functional outcomes of combining ceramic block with osteogenic-induced mesenchymal stem cells and platelet-rich plasma (TEB) to repair critical-sized segmental tibial defect. Comparisons were made with fresh marrow-impregnated ceramic block (MIC) and partially demineralized allogeneic bone block (ALLO). Six New Zealand White female rabbits were used in each study group and three rabbits with no implants were used as negative controls. By Day 90, 4/6 rabbits in TEB group and 2/6 in ALLO and MIC groups resumed normal gait pattern. Union was achieved significantly faster in TEB group with a radiological score of 4.50 ± 0.78 versus ALLO (1.06 ± 0.32), MIC (1.28 ± 0.24), and negative controls (0). Histologically, TEB group scored the highest percentage of new bone (82% ± 5.1%) compared to ALLO (5% ± 2.5%) and MIC (26% ± 5.2%). Biomechanically, TEB-treated tibiae achieved the highest compressive strength (43.50 ± 12.72 MPa) compared to those treated with ALLO (15.15 ± 3.57 MPa) and MIC (23.28 ± 6.14 MPa). In conclusion, TEB can repair critical-sized segmental load-bearing bone defects and restore limb function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.