Evidence map›Paper›PMID 25165597›Full record

ArticleJournal of the Royal Society, Interface2014

The interplay of cell-cell and cell-substrate adhesion in collective cell migration.

Chenlu Wang, Sagar Chowdhury, Meghan Driscoll, Carole A Parent, S K Gupta, Wolfgang Losert

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 36 citations in OpenAlex.

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  11. The front and rear of collective cell migration.Nature reviews. Molecular cell biology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chenlu WangBiophysics Graduate Program, University of Maryland, College Park, MD 20742, USA Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Bethesda, MD 20892, USA clwang@umd.edu.
Sagar ChowdhuryDepartment of Mechanical Engineering and the Institute for Systems Research, University of Maryland, College Park, MD 20742, USA.
Meghan DriscollDepartment of Physics, University of Maryland, College Park, MD 20742, USA.
Carole A ParentLaboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Bethesda, MD 20892, USA Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA.
S K GuptaDepartment of Mechanical Engineering and the Institute for Systems Research, University of Maryland, College Park, MD 20742, USA.
Wolfgang LosertDepartment of Physics, University of Maryland, College Park, MD 20742, USA Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742, USA.
University of Maryland, College Park · USCenter for Cancer Research · US

Funding

Signaling Events Regulating ChemotaxisZIABC010418 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PARENT, CAROLE · 2009 to 2017
$4.6M
Intramural NIH HHS
6 · The paper itself

Abstract

Collective cell migration often involves notable cell-cell and cell-substrate adhesions and highly coordinated motion of touching cells. We focus on the interplay between cell-substrate adhesion and cell-cell adhesion. We show that the loss of cell-surface contact does not significantly alter the dynamic pattern of protrusions and retractions of fast migrating amoeboid cells (Dictyostelium discoideum), but significantly changes their ability to adhere to other cells. Analysis of the dynamics of cell shapes reveals that cells that are adherent to a surface may coordinate their motion with neighbouring cells through protrusion waves that travel across cell-cell contacts. However, while shape waves exist if cells are detached from surfaces, they do not couple cell to cell. In addition, our investigation of actin polymerization indicates that loss of cell-surface adhesion changes actin polymerization at cell-cell contacts. To further investigate cell-cell/cell-substrate interactions, we used optical micromanipulation to form cell-substrate contact at controlled locations. We find that both cell-shape dynamics and cytoskeletal activity respond rapidly to the formation of cell-substrate contact.

Indexed as

ActinsCytoskeletonDictyosteliumProtozoan ProteinsActinsProtozoan Proteinsactin polymerizationcell–cell adhesioncell migrationcell-shape dynamicscell–substrate adhesionDictyostelium discoideum

Identifiers

PMID25165597
PMCPMC4191097
OpenAlexW2109138194

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.