ReviewTherapeutic advances in infectious disease2013
Viral infections and the development of asthma in children.
Review in Therapeutic advances in infectious disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Antibiotic treatment for non-specific upper respiratory tract infections and exacerbation risk in children with asthma: a target trial emulation study.American journal of epidemiology · 2026Article
- Allergic sensitization and respiratory infection in infancy-Too early for two-hits on lung function?Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Sex Differences in Lung Immunity.Immunological reviews · 2026Review
- Wheezing on admission: a marker for bronchiolitis severity and asthma development.Pediatric research · 2025Article
- Early-life RSV infection modulates innate immune events, preferentially enhancing allergen-induced type 2 lung inflammation in females.PLoS pathogens · 2025Article
- Cord blood sphingolipids are associated with atopic dermatitis and wheeze in the first year of life.The journal of allergy and clinical immunology. Global · 2022Article
- Association between early viral lower respiratory tract infections and subsequent asthma development.World journal of critical care medicine · 2022Article
- Cytokine Inductions and Intracellular Signal Profiles by Stimulation of dsRNA and SEB in the Macrophages and Epithelial Cells.Immune network · 2022Article
- The temporal pattern and lifestyle associations of respiratory virus infection in a cohort study spanning the first two years of life.BMC pediatrics · 2022Article
- Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma.Frontiers in immunology · 2022Review
- When is asthma not guilty?International journal of pediatrics & adolescent medicine · 2021Review
- The interplay between airway epithelium and the immune system - A primer for the respiratory clinician.Paediatric respiratory reviews · 2021Review
- Bronchiolitis and recurrent wheezing are distinguished by type 2 innate lymphoid cells and immune response.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Article
- New onset asthma during pregnancy: two case reports.F1000Research · 2021Article
- Wheezing-Related Relevant Factors and the Role of Viral Bronchiolitis.Frontiers in allergy · 2021Review
- Positive association of breastfeeding on respiratory syncytial virus infection in hospitalized infants: a multicenter retrospective study.Clinical and experimental pediatrics · 2020Article
- Effect of acute respiratory infections in infancy on pulmonary function test at 3 years of age: a prospective birth cohort study.BMJ open respiratory research · 2020Article
- Hospitalization, Asthma Phenotypes, and Readmission Rates in Pre-school Asthma.Frontiers in pediatrics · 2020Article
- RSV hospitalization in infancy increases the risk of current wheeze at age 6 in late preterm born children without atopic predisposition.European journal of pediatrics · 2019Article
- Association of specific viral infections with childhood asthma exacerbations.Interventional medicine & applied science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Viral aetiology, host susceptibility (in particular allergic predisposition and sensitization), and illness severity, timing and frequency all appear to contribute as synergistic factors to the risk of developing asthma. Experimental models have shown both innate and adaptive immune responses contribute to this risk with lung inflammatory cells showing marked differences in phenotype and function in young compared with older animals, and these differences are further enhanced following virus infection. Findings to date strongly suggest that the impact of infant and preschool viral infections on the maturing immune system and developing lung that subsequently result in an asthma phenotype occur during a critical susceptibility period, and in a genetically susceptible host. There are currently no therapeutic strategies that allow primary or secondary prevention of asthma following early life viral respiratory infections in high-risk children, thus a focus on understanding the mechanisms of progression from viral wheezing in infants and preschool children to asthma development are urgently needed. This review summarizes the data reporting the role of the two most common viruses, that is, respiratory syncytial virus and human rhinovirus, that result in asthma development, comparing risk factors for disease progression, and providing insight into strategies that might be adopted to prevent asthma development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.