Evidence map›Paper›PMID 25165446›Full record

ArticleFrontiers in aging neuroscience2014

Not only cardiovascular, but also coordinative exercise increases hippocampal volume in older adults.

Claudia Niemann, Ben Godde, Claudia Voelcker-Rehage

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07435506 (Performing Fitts' Tasks in Virtual Reality With and Without Augmented Feedback), which is not on this map. Cited by 93 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07435506 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Performing Fitts' Tasks in Virtual Reality With and Without Augmented Feedback: a Comparison Between Young and Older Adults

TypeinterventionalSponsorAix Marseille UniversitéRan2026 to 2026Enrolled30ConditionsHealthy Older Adults, Healthy Young AdultsArmsVR-augmented specific feedback, VR-augmented global feedback, R-intrinsic feedback, VR-intrinsic feedback
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Claudia NiemannJacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen Bremen, Germany.
Ben GoddeJacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen Bremen, Germany ; AgeAct Research Center, Jacobs University Bremen Bremen, Germany.
Claudia Voelcker-RehageJacobs Center on Lifelong Learning and Institutional Development, Jacobs University Bremen Bremen, Germany ; AgeAct Research Center, Jacobs University Bremen Bremen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular activity has been shown to be positively associated with gray and white matter volume of, amongst others, frontal and temporal brain regions in older adults. This is particularly true for the hippocampus, a brain structure that plays an important role in learning and memory, and whose decline has been related to the development of Alzheimer's disease. In the current study, we were interested in whether not only cardiovascular activity but also other types of physical activity, i.e., coordination training, were also positively associated with the volume of the hippocampus in older adults. For this purpose we first collected cross-sectional data on "metabolic fitness" (cardiovascular fitness and muscular strength) and "motor fitness" (e.g., balance, movement speed, fine coordination). Second, we performed a 12-month randomized controlled trial. Results revealed that motor fitness but not metabolic fitness was associated with hippocampal volume. After the 12-month intervention period, both, cardiovascular and coordination training led to increases in hippocampal volume. Our findings suggest that a high motor fitness level as well as different types of physical activity were beneficial to diminish age-related hippocampal volume shrinkage or even increase hippocampal volume.

Indexed as

brain agingcardiovascular fitnesshippocampusmotor fitnessphysical activity

Identifiers

PMID25165446
PMCPMC4131191

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.