ArticlePlant physiology2014
FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis.
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Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed.
- Mitochondrial dynamics resolve physical-social tensions and challenges through adaptable multi-objective optimisation.bioRxiv : the preprint server for biology · 2026Article
- PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance.The Plant journal : for cell and molecular biology · 2026Review
- Ubiquitin-dependent mitochondrial protein degradation ensures seedling emergence by regulating ER-mitochondrial interaction and mitophagy.Nature plants · 2026Article
- PMF proteins mediate mitochondrial fusion in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2026Article
- MDP25-VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A central role for PINK1 in governing local mitochondrial biogenesis and degradation in neurons.Cellular and molecular life sciences : CMLS · 2026Review
- Autophagy in plants: molecular mechanisms and roles in abiotic stress responses.Frontiers in plant science · 2026Review
- Genomic-Encoded Mitovirus RdRp Is Required for Embryo Development and Maintaining Mitochondrial Dynamics inInternational journal of molecular sciences · 2025Article
- Mitochondrial proteases and their roles in mitophagy in plants, animals, and yeast.Plant & cell physiology · 2025Review
- Cytoplasmic inheritance: The transmission of plastid and mitochondrial genomes across cells and generations.Plant physiology · 2025Review
- Mitophagy in plants: Emerging regulators of mitochondrial targeting for selective autophagy.Journal of microscopy · 2025Review
- Stress granules sequester autophagy proteins to facilitate plant recovery from heat stress.Nature communications · 2024Article
- COI1 F-box proteins regulate DELLA protein levels, growth, and photosynthetic efficiency in maize.The Plant cell · 2024Article
- Evolution and maintenance of mtDNA gene content across eukaryotes.The Biochemical journal · 2024Review
- CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy.Science advances · 2024Article
- A molecular atlas of plastid and mitochondrial proteins reveals organellar remodeling during plant evolutionary transitions from algae to angiosperms.PLoS biology · 2024Article
- Did mitophagy follow the origin of mitochondria?Autophagy · 2024Review
- Isolation of Cytosolic Ribosomes Associated with Plant Mitochondria and Chloroplasts.Methods in molecular biology (Clifton, N.J.) · 2024Article
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13 authors.
Amr M El ZawilyDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Markus SchwarzländerDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Iris FinkemeierDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Iain G JohnstonDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Abdelilah BenamarDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Yongguo CaoDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Clémence GissotDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Andreas J MeyerDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Ken WilsonDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
Raju DatlaDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
David MacherelDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).ORCID http://orcid.org/0000-0002-3352-2185
Nick S JonesDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.).
David C LoganDepartment of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E2 (A.M.E.Z., K.W., D.C.L.);Faculty of Science, Damanhour University, Damanhour 22516, Egypt (A.M.E.Z.);Institute of Crop Science and Resource Conservation, University of Bonn, D-53113 Bonn, Germany (M.S., A.J.M.);Max-Planck-Institute for Plant Breeding Research, Plant Proteomics Group, 50829 Cologne, Germany (I.F.);Department of Mathematics, Imperial College London, London SW7 2AZ, United Kingdom (I.G.J., C.G., N.S.J.);Université d'Angers, Institut National de la Recherche Agronomique, and Agrocampus Ouest, Unité Mixte de Recherche 1345, Institut de Recherche en Horticulture et Semences, Angers F-49045, France (A.B., D.M., D.C.L.); andPlant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan S7N 0W9, Canada (Y.C., R.D.) david.logan@univ-angers.fr.ORCID http://orcid.org/0000-0002-8980-240X
Funding
Biotechnology and Biological Sciences Research Council BB/C000129/1Medical Research Council MR/J013617/1
Abstract
Mitochondria are defining components of most eukaryotes. However, higher plant mitochondria differ biochemically, morphologically, and dynamically from those in other eukaryotes. FRIENDLY, a member of the CLUSTERED MITOCHONDRIA superfamily, is conserved among eukaryotes and is required for correct distribution of mitochondria within the cell. We sought to understand how disruption of FRIENDLY function in Arabidopsis (Arabidopsis thaliana) leads to mitochondrial clustering and the effects of this aberrant chondriome on cell and whole-plant physiology. We present evidence for a role of FRIENDLY in mediating intermitochondrial association, which is a necessary prelude to mitochondrial fusion. We demonstrate that disruption of mitochondrial association, motility, and chondriome structure in friendly affects mitochondrial quality control and leads to mitochondrial stress, cell death, and strong growth phenotypes.
Indexed as
ActinsArabidopsisArabidopsis ProteinsCytoskeletonMembrane Potential, MitochondrialMitochondriaPhotosynthesisTranscriptomeActinsArabidopsis Proteins
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