ArticleJournal of clinical microbiology2014
Evaluation of anatomically designed flocked rectal swabs for molecular detection of enteric pathogens in children admitted to hospital with severe gastroenteritis in Botswana.
Article in Journal of clinical microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- Comparison of a Rapid Multiplex Gastrointestinal Panel with Standard Laboratory Testing in the Management of Children with Hematochezia in a Pediatric Emergency Department: Randomized Controlled Trial.Microbiology spectrum · 2023Trial
- Optimising the management of childhood acute diarrhoeal disease using a rapid test-and- treat strategy and/orBMJ global health · 2022Trial
- Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children.The New England journal of medicine · 2018Trial
- Trial
- The aetiology of diarrhoea, pneumonia and respiratory colonization of HIV-exposed infants randomized to breast- or formula-feeding.Paediatrics and international child health · 2016Trial
- OptimizingJournal of clinical microbiology · 2026Observational
- Using short-read 16S rRNA sequencing of multiple variable regions to generate high-quality results to a species level.Frontiers in bioinformatics · 2025Article
- Article
- Comparison of rectal swabs and fecal samples for the detection ofMicrobiology spectrum · 2024Article
- Article
- Molecular detection and genotype analysis of Kudoa septempunctata from food poisoning outbreaks in Korea.Parasites, hosts and diseases · 2023Article
- Acute Viral Gastrointestinal (GI) Infections in the Tropics-A Role for Cartridge-Based Multiplex PCR Panels?Tropical medicine and infectious disease · 2022Review
- Influenza virus detection in the stool of children with acute gastroenteritis.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- Rectal Swabs as an Alternative Sample Collection Method to Bulk Stool for the Real-Time PCR Detection ofThe American journal of tropical medicine and hygiene · 2020Article
- Evaluation of the FecalSwab for Stool Specimen Storage and Molecular Detection of Enteropathogens on the BD Max System.Journal of clinical microbiology · 2020Article
- Ensemble forecast and parameter inference of childhood diarrhea in Chobe District, Botswana.Epidemics · 2020Article
- Prevalence ofThe Pan African medical journal · 2020Article
- El Niño-Southern oscillation and under-5 diarrhea in Botswana.Nature communications · 2019Article
- Evaluation of Anatomically Designed Flocked Rectal Swabs for Use with the BioFire FilmArray Gastrointestinal Panel for Detection of Enteric Pathogens in Children Admitted to Hospital with Severe Gastroenteritis.Journal of clinical microbiology · 2019Article
- Diversity of Rotavirus Strains Circulating in Botswana before and after introduction of the Monovalent Rotavirus Vaccine.Vaccine · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Two-hundred eighty matched bulk stool and anatomically designed flocked rectal swab samples were collected from children admitted to the hospital with acute diarrhea in Botswana. Their parents were asked about the acceptability of the swab collection method compared with bulk stool sampling. All samples underwent identical testing with a validated 15-target (9 bacterial, 3 viral, and 3 parasite) commercial multiplex PCR assay. The flocked swabs had a 12% higher yield for bacterial pathogen targets (241 versus 212; P = 0.003) compared with that of stool samples, as well as similar yields for viral targets (110 versus 113; P = 0.701) and parasite targets (59 versus 65; P = 0.345). One hundred sixty-four of the flocked swab-stool pairs were also tested with separate laboratory-developed bacterial and viral multiplex assays, and the flocked rectal swabs had a performance that was similar to that seen with commercial assay testing. Almost all parents/guardians found the swabs acceptable. Flocked rectal swabs significantly facilitate the molecular diagnosis of diarrheal disease in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.