Evidence map›Paper›PMID 25165032›Full record

ArticleAnnals of the rheumatic diseases2015

Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK clinical practice research datalink.

Lorna E Clarson, Samantha L Hider, John Belcher, Carl Heneghan, Edward Roddy, Christian D Mallen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 124 citations in OpenAlex.

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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lorna E ClarsonResearch Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, UK.
Samantha L HiderResearch Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, UK.
John BelcherResearch Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, UK.
Carl HeneghanDepartment of Primary Care Health Sciences, Oxford University, Oxford, UK.
Edward RoddyResearch Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, UK.
Christian D MallenResearch Institute for Primary Care & Health Sciences, Keele University, Keele, Staffordshire, UK.
Keele University · GBUniversity of Oxford · GB

Funding

Department of Health WMCLAHRC-2014-1Versus Arthritis 19634
6 · The paper itself

Abstract

objectivesTo determine whether gout increases risk of incident coronary heart disease (CHD), cerebrovascular (CVD) and peripheral vascular disease (PVD) in a large cohort of primary care patients with gout, since there have been no such large studies in primary care.

methodsA retrospective cohort study was performed using data from the Clinical Practice Research Datalink (CPRD). Risk of incident CHD, CVD and PVD was compared in 8386 patients with an incident diagnosis of gout, and 39 766 age, sex and registered general practice-matched controls, all aged over 50 years and with no prior vascular history, in the 10 years following incidence of gout, or matched index date (baseline). Multivariable Cox Regression was used to estimate HRs and covariates included sex and baseline measures of age, Body Mass Index, smoking, alcohol consumption, Charlson comorbidity index, history of hypertension, hyperlipidaemia, chronic kidney disease, statin use and aspirin use.

resultsMultivariable analysis showed men were at increased risk of any vascular event (HRs (95% CIs)) HR 1.06 (1.01 to 1.12), any CHD HR 1.08 (1.01 to 1.15) and PVD HR 1.18 (1.01 to 1.38), while women were at increased risk of any vascular event, HR 1.25 (1.15 to 1.35), any CHD HR 1.25 (1.12 to 1.39), and PVD 1.89 (1.50 to 2.38)) but not any CVD.

conclusionsIn this cohort of over 50s with gout, female patients with gout were at greatest risk of incident vascular events, even after adjustment for vascular risk factors, despite a higher prevalence of both gout and vascular disease in men. Further research is required to establish the reason for this sex difference.

Indexed as

AgedCardiovascular DiseasesCerebrovascular DisordersCohort StudiesCoronary DiseaseFemaleGoutHumansMaleMiddle AgedPeripheral Vascular DiseasesRetrospective StudiesSex FactorsStatistics as TopicUnited KingdomCardiovascular DiseaseEpidemiologyGout

Identifiers

PMID25165032
PMCPMC4392302
OpenAlexW2153881026

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.