ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Evidence of Preserved Oxidative Capacity and Oxygen Delivery in the Plantar Flexor Muscles With Age.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Pooled it
- Neither intracellular oxygen availability nor mitochondrial coupling explain lower oxidative capacity in older human vastus lateralis muscle in vivo.The Journal of physiology · 2026Article
- Reduced oxidative capacity of skeletal muscle mitochondria IS a fundamental consequence of adult ageing.The Journal of physiology · 2025Article
- Muscle oxygen consumption and microvascular function in healthy aging assessed by near-infrared spectroscopy: effect of adipose tissue thickness and physical fitness.Frontiers in physiology · 2025Article
- Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults.GeroScience · 2024Article
- A systematic review of the relationship between muscle oxygen dynamics and energy rich phosphates. Can NIRS help?BMC sports science, medicine & rehabilitation · 2024Article
- In vivo assessment of mitochondrial capacity using NIRS in locomotor muscles of young and elderly males with similar physical activity levels.GeroScience · 2020Article
- Review
- Moderate-to-Vigorous Physical Activity Is Associated With Higher Muscle Oxidative Capacity in Older Adults.Journal of the American Geriatrics Society · 2019Article
- Oxygen availability and skeletal muscle oxidative capacity in patients with peripheral artery disease: implications from in vivo and in vitro assessments.American journal of physiology. Heart and circulatory physiology · 2018Article
- Sex-specific impact of aging on the blood pressure response to exercise.American journal of physiology. Heart and circulatory physiology · 2018Article
- Structure and function of human muscle fibres and muscle proteome in physically active older men.The Journal of physiology · 2017Article
- Skeletal muscle bioenergetics in aging and heart failure.Heart failure reviews · 2017Review
- Muscle oxygenation during dynamic plantar flexion exercise: combining BOLD MRI with traditional physiological measurements.Physiological reports · 2016Article
- Molecular studies of exercise, skeletal muscle, and ageing.F1000Research · 2016Review
- Impact of age on exercise-induced ATP supply during supramaximal plantar flexion in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
Abstract
Studies examining the effect of aging on skeletal muscle oxidative capacity have yielded equivocal results; however, these investigations may have been confounded by differences in oxygen (O(2)) delivery, physical activity, and small numbers of participants. Therefore, we evaluated skeletal muscle oxidative capacity and O(2) delivery in a relatively large group (N = 40) of young (22 ± 2 years) and old (73 ± 7 years) participants matched for physical activity. After submaximal dynamic plantar flexion exercise, phosphocreatine (PCr) resynthesis ((31)P magnetic resonance spectroscopy), muscle reoxygenation (near-infrared spectroscopy), and popliteal artery blood flow (Doppler ultrasound) were measured. The phosphocreatine recovery time constant (Tau) (young: 33 ± 16; old: 30 ± 11 seconds), maximal rate of adenosine triphosphate (ATP) synthesis (young: 25 ± 9; old: 27 ± 8 mM/min), and muscle reoxygenation rates determined by the deoxyhemoglobin/myoglobin recovery Tau (young: 48 ± 5; old: 47 ± 9 seconds) were similar between groups. Similarly, although tending to be higher in the old, there were no significant age-related differences in postexercise popliteal blood flow (area under the curve: young: 1,665 ± 227 vs old: 2,404 ± 357 mL, p = .06) and convective O(2) delivery (young: 293 ± 146 vs old: 404 ± 191 mL, p = .07). In conclusion, when physical activity and O(2) delivery are similar, oxidative capacity in the plantar flexors is not affected by aging. These findings reveal that diminished skeletal muscle oxidative capacity is not an obligatory accompaniment to the aging process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.