ArticleJournal of the American Heart Association2014
Plasma phospholipid trans-fatty acids levels, cardiovascular diseases, and total mortality: the cardiovascular health study.
Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies.BMJ (Clinical research ed.) · 2015Pooled it
- Circulating and dietary trans fatty acids and incident type 2 diabetes in older adults: the Cardiovascular Health Study.Diabetes care · 2015Trial
- Blood biomarkers of trans-fatty acid intake among Nigerian adults in the Federal Capital Territory: a cross-sectional study.The American journal of clinical nutrition · 2025Article
- Association of plasma trans fatty acid concentrations with blood pressure and hypertension in U.S. adults.Frontiers in endocrinology · 2024Article
- Plasma Metabolite Profiles Following Consumption of Animal Protein and Soybean-Based Diet in Hypercholesterolemic Postmenopausal Women.Metabolites · 2022Article
- The Association Between Circulating Trans Fatty Acids and Thyroid Function Measures in U.S. Adults.Frontiers in endocrinology · 2022Article
- Effects of Different Roughage Diets on Fattening Performance, Meat Quality, Fatty Acid Composition, and Rumen Microbe in Steers.Frontiers in nutrition · 2022Article
- Picky Eating in School-Aged Children: Sociodemographic Determinants and the Associations with Dietary Intake.Nutrients · 2021Article
- Position Statement on Fat Consumption and Cardiovascular Health - 2021.Arquivos brasileiros de cardiologia · 2021Article
- A Review of Lipidomics of Cardiovascular Disease Highlights the Importance of Isolating Lipoproteins.Metabolites · 2020Review
- Measuring nutritional knowledge using Item Response Theory and its validity in European adolescents.Public health nutrition · 2019Article
- Endoplasmic reticulum stress may be involved in insulin resistance and lipid metabolism disorders of the white adipose tissues induced by high-fat diet containing industrial trans-fatty acids.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Preconception Plasma Phospholipid Fatty Acids and Fecundability.The Journal of clinical endocrinology and metabolism · 2018Article
- Replacement of saturated and trans-fatty acids in the diet v. CVD risk in the light of the most recent studies.Public health nutrition · 2018Review
- New plasma preparation approach to enrich metabolome coverage in untargeted metabolomics: plasma protein bound hydrophobic metabolite release with proteinase K.Scientific reports · 2018Article
- Correlation of trans fatty acids with the severity of coronary artery disease lesions.Lipids in health and disease · 2018Article
- Plasma trans-fatty acids levels and mortality: a cohort study based on 1999-2000 National Health and Nutrition Examination Survey (NHANES).Lipids in health and disease · 2017Article
- The relationship of plasma Trans fatty acids with dietary inflammatory index among US adults.Lipids in health and disease · 2017Article
- Trans-fatty acid levels in erythrocytes in Europe.European journal of nutrition · 2017Article
- PlasmaThe Journal of nutrition · 2017Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
backgroundWhile self-reported trans-fatty acid (TFA) consumption is linked to coronary heart disease (CHD), relationships between objective biomarkers of TFA subtypes (t-16:1n9, total t-18:1, and cis/trans-(c/t-), t/c- and t/t-18:2) and cardiovascular disease (CVD) or total mortality are not well established. METHODS AND
resultsWe evaluated 2742 adults in the Cardiovascular Health Study, aged 74±5 years and free of prevalent CVD, with plasma phospholipid TFA measures in 1992. Incident fatal and nonfatal CHD events, CVD and non-CVD mortality, and total mortality were centrally adjudicated through 2010. Risks were assessed using Cox proportional hazards. During 31 494 person-years, 1735 total deaths and 639 total CHD events occurred. In the multivariate model including mutual adjustment for the 5 TFA subtypes, circulating t/t-18:2 was associated with higher total mortality (extreme quintile hazard ratio (HR)=1.23, 95% CI=1.04 to 1.44, P-trend=0.01), CVD mortality (HR=1.40, 95% CI=1.05 to 1.86, P-trend=0.02), and total CHD (HR=1.39, 95% CI=1.06 to 1.83, P-trend=0.01). t/c-18:2 was positively related to total mortality (HR=1.19, P-trend=0.05), total CHD (HR=1.67, P-trend=0.002), and nonfatal CHD (HR=2.06, P-trend=0.002) after mutual adjustment; these associations were insignificant without mutual adjustment. Neither t-16:1n9 nor t-18:1 was significantly associated with total mortality or CVD, nor was c/t-18:2 if we excluded early cases.
conclusionsAmong circulating TFAs, t/t-18:2 was most adversely associated with total mortality, mainly due to the increased risk of CVD. t/c-18:2 was also positively associated with total mortality and CHD, but only after adjustment for other TFAs. These results highlight the need for further investigation of dietary sources, nondietary determinants, and health effects of specific TFA subtypes, especially t-18:2 isomers.
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