ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Differential regulation of cone calcium signals by different horizontal cell feedback mechanisms in the mouse retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- A heterogeneous population code at the first synapse of vision.Nature communications · 2026Article
- Article
- Ancestral photoreceptor diversity as the basis of visual behaviour.Nature ecology & evolution · 2024Review
- Super-resolution STED imaging in the inner and outer whole-mount mouse retina.Frontiers in ophthalmology · 2023Article
- Suppression without inhibition: how retinal computation contributes to saccadic suppression.Communications biology · 2022Article
- Review
- Retinal horizontal cells use different synaptic sites for global feedforward and local feedback signaling.Current biology : CB · 2022Article
- Neural circuits in the mouse retina support color vision in the upper visual field.Nature communications · 2020Article
- Vesicular Release of GABA by Mammalian Horizontal Cells Mediates Inhibitory Output to Photoreceptors.Frontiers in cellular neuroscience · 2020Review
- Horizontal Cell Feedback to Cone Photoreceptors in Mammalian Retina: Novel Insights From the GABA-pH Hybrid Model.Frontiers in cellular neuroscience · 2020Review
- Article
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
- Rod Bipolar Cells Require Horizontal Cells for Invagination Into the Terminals of Rod Photoreceptors.Frontiers in cellular neuroscience · 2019Article
- Eliminating Glutamatergic Input onto Horizontal Cells Changes the Dynamic Range and Receptive Field Organization of Mouse Retinal Ganglion Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Connectomics of synaptic microcircuits: lessons from the outer retina.The Journal of physiology · 2017Review
- How do horizontal cells 'talk' to cone photoreceptors? Different levels of complexity at the cone-horizontal cell synapse.The Journal of physiology · 2017Review
- Versatile functional roles of horizontal cells in the retinal circuit.Scientific reports · 2017Article
- Membrane-associated guanylate kinase scaffolds organize a horizontal cell synaptic complex restricted to invaginating contacts with photoreceptors.The Journal of comparative neurology · 2017Article
- Article
- Synaptic Ribbon Active Zones in Cone Photoreceptors Operate Independently from One Another.Frontiers in cellular neuroscience · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Controlling neurotransmitter release by modulating the presynaptic calcium level is a key mechanism to ensure reliable signal transmission from one neuron to the next. In this study, we investigated how the glutamatergic output of cone photoreceptors (cones) in the mouse retina is shaped by different feedback mechanisms from postsynaptic GABAergic horizontal cells (HCs) using a combination of two-photon calcium imaging and pharmacology at the level of individual cone axon terminals. We provide evidence that hemichannel-mediated (putative ephaptic) feedback sets the cone output gain by defining the basal calcium level, a mechanism that may be crucial for adapting cones to the ambient light level. In contrast, pH-mediated feedback did not modulate the cone basal calcium level but affected the size and shape of light-evoked cone calcium signals in a contrast-dependent way: low-contrast light responses were amplified, whereas high-contrast light responses were reduced. Finally, we provide functional evidence that GABA shapes light-evoked calcium signals in cones. Because we could not localize ionotropic GABA receptors on cone axon terminals using electron microscopy, we suggest that GABA may act through GABA autoreceptors on HCs, thereby possibly modulating hemichannel- and/or pH-mediated feedback. Together, our results suggest that at the cone synapse, hemichannel-mediated (ephaptic) and pH-mediated feedback fulfill distinct functions to adjust the output of cones to changing ambient light levels and stimulus contrasts and that the efficacy of these feedback mechanisms is likely modulated by GABA release in the outer retina.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.