ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Fast phasic release properties of dopamine studied with a channel biosensor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Nicotine-mediated therapy for Parkinson's disease in transgenicFrontiers in aging neuroscience · 2024Article
- Mini-review: The Role of the Cerebellum in Visuomotor Adaptation.Cerebellum (London, England) · 2022Review
- Spatial and temporal scales of dopamine transmission.Nature reviews. Neuroscience · 2021Review
- Nanostructures for Biosensing, with a Brief Overview on Cancer Detection, IoT, and the Role of Machine Learning in Smart Biosensors.Sensors (Basel, Switzerland) · 2021Review
- Mechanisms and regulation of dopamine release.Current opinion in neurobiology · 2019Review
- Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and Glutamate.Cell reports · 2018Article
- Antagonistic effect of dopamine structural analogues on human GABAρ1 receptor.Scientific reports · 2017Article
- Cholinergic Interneurons Underlie Spontaneous Dopamine Release in Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission.Scientific reports · 2016Article
- Striatal dopamine neurotransmission: regulation of release and uptake.Basal ganglia · 2016Article
- Mechanisms and functions of GABA co-release.Nature reviews. Neuroscience · 2016Review
- Dopamine directly modulates GABAA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Carbon nanotube biosensors.Frontiers in chemistry · 2015Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Few other neurotransmitters are of as intense interest to neuropsychiatry and neurology as dopamine, yet existing techniques to monitor dopamine release leave an important spatiotemporal gap in our understanding. Electrochemistry and fluorescence imaging tools have been developed to fill the gap, but these methods have important limitations. We circumvent these limitations by introducing a dopamine-gated chloride channel into rat dorsal striatal medium spiny neurons, targets of strong dopamine innervation, thereby transforming dopamine from a slow transmitter into a fast transmitter and revealing new opportunities for studying moment-to-moment regulation of dopamine release. We demonstrate pharmacological and biophysical properties of the channel that make it suitable for fast, local dopamine measurements, and we demonstrate for the first time spontaneous and evoked responses to vesicular dopamine release in the dorsal striatum. Evoked dopamine currents were separated into a fast, monosynaptic component and a slower-rising and decaying disynaptic component mediated by nicotinic receptor activation. In summary, LGC-53 represents a dopamine biosensor with properties suitable for temporal separation of distinct dopamine signals in targets of dopamine innervation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.