ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Frequency-dependent, cell type-divergent signaling in the hippocamposeptal projection.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Medial septum parvalbumin-expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome.Epilepsia · 2025Article
- Regulation of Hippocamposeptal Synaptic Transmission by GABAJournal of molecular neuroscience : MN · 2024Article
- The medial septum controls hippocampal supra-theta oscillations.Nature communications · 2023Article
- Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior.Scientific reports · 2023Article
- Hippocampal non-theta state: The "Janus face" of information processing.Frontiers in neural circuits · 2023Review
- Inhibitory hippocampus-medial septum projection controls locomotion and exploratory behavior.Frontiers in synaptic neuroscience · 2023Article
- Epilepsy-associated increase in gonadotropin-releasing hormone neuron firing in diestrous female mice is independent of chronic seizure burden severity.Epilepsy research · 2022Article
- The spatiotemporal organization of experience dictates hippocampal involvement in primary visual cortical plasticity.Current biology : CB · 2021Article
- Regulation of hippocamposeptal input within the medial septum/diagonal band of Broca.Neuropharmacology · 2021Article
- Article
- A model of cholinergic suppression of hippocampal ripples through disruption of balanced excitation/inhibition.Hippocampus · 2019Article
- GABAergic Medial Septal Neurons with Low-Rhythmic Firing Innervating the Dentate Gyrus and Hippocampal Area CA3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Septo-hippocampal interaction.Cell and tissue research · 2018Review
- Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice.Journal of visualized experiments : JoVE · 2018Article
- Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons.Journal of neuroscience research · 2017Article
- Article
- Integration of optogenetics with complementary methodologies in systems neuroscience.Nature reviews. Neuroscience · 2017Review
- Gain Modulation of Cholinergic Neurons in the Medial Septum-Diagonal Band of Broca Through Hyperpolarization.Hippocampus · 2016Article
- Serotonin increases synaptic activity in olfactory bulb glomeruli.Journal of neurophysiology · 2016Article
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Authors and funding
9 authors.
Funding
Abstract
Hippocampal oscillations are critical for information processing, and are strongly influenced by inputs from the medial septum. Hippocamposeptal neurons provide direct inhibitory feedback from the hippocampus onto septal cells, and are therefore likely to also play an important role in the circuit; these neurons fire at either low or high frequency, reflecting hippocampal network activity during theta oscillations or ripple events, respectively. Here, we optogenetically target the long-range GABAergic projection from the hippocampus to the medial septum in rats, and thereby simulate hippocampal input onto downstream septal cells in an acute slice preparation. In response to optogenetic activation of hippocamposeptal fibers at theta and ripple frequencies, we elicit postsynaptic GABAergic responses in a subset (24%) of septal cells, most predominantly in fast-spiking cells. In addition, in another subset of septal cells (19%) corresponding primarily to cholinergic cells, we observe a slow hyperpolarization of the resting membrane potential and a decrease in input resistance, particularly in response to prolonged high-frequency (ripple range) stimulation. This slow response is partially sensitive to GIRK channel and D2 dopamine receptor block. Our results suggest that two independent populations of septal cells distinctly encode hippocampal feedback, enabling the septum to monitor ongoing patterns of activity in the hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.