ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Engrailed alters the specificity of synaptic connections of Drosophila auditory neurons with the giant fiber.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Innexin expression and localization in the Drosophila antenna indicate gap junction or hemichannel involvement in antennal chemosensory sensilla.Cell and tissue research · 2024Article
- Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival.Development (Cambridge, England) · 2024Article
- Organization of an Ascending Circuit that Conveys Flight Motor State.bioRxiv : the preprint server for biology · 2023Article
- Developmental Biology in Central America, the northern region of South America and the Caribbean.The International journal of developmental biology · 2021Review
- Wiring patterns from auditory sensory neurons to the escape and song-relay pathways in fruit flies.The Journal of comparative neurology · 2020Article
- Spatial Comparisons of Mechanosensory Information Govern the Grooming Sequence in Drosophila.Current biology : CB · 2020Article
- Article
- Fast intensity adaptation enhances the encoding of sound in Drosophila.Nature communications · 2018Article
- Article
- Active Mechanisms of Vibration Encoding and Frequency Filtering in Central Mechanosensory Neurons.Neuron · 2017Article
- FluoRender: joint freehand segmentation and visualization for many-channel fluorescence data analysis.BMC bioinformatics · 2017Article
- Shaking B Mediates Synaptic Coupling between Auditory Sensory Neurons and the Giant Fiber of Drosophila melanogaster.PloS one · 2016Article
- Hearing in Drosophila.Current opinion in neurobiology · 2015Review
- Article
- Engrailed homeoproteins in visual system development.Cellular and molecular life sciences : CMLS · 2015Review
- Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
We show that a subset of sound-detecting Johnston's Organ neurons (JONs) in Drosophila melanogaster, which express the transcription factors Engrailed (En) and Invected (Inv), form mixed electrical and chemical synaptic inputs onto the giant fiber (GF) dendrite. These synaptic connections are detected by trans-synaptic Neurobiotin (NB) transfer and by colocalization of Bruchpilot-short puncta. We then show that misexpressing En postmitotically in a second subset of sound-responsive JONs causes them to form ectopic electrical and chemical synapses with the GF, in turn causing that postsynaptic neuron to redistribute its dendritic branches into the vicinity of these afferents. We also introduce a simple electrophysiological recording paradigm for quantifying the presynaptic and postsynaptic electrical activity at this synapse, by measuring the extracellular sound-evoked potentials (SEPs) from the antennal nerve while monitoring the likelihood of the GF firing an action potential in response to simultaneous subthreshold sound and voltage stimuli. Ectopic presynaptic expression of En strengthens the synaptic connection, consistent with there being more synaptic contacts formed. Finally, RNAi-mediated knockdown of En and Inv in postmitotic neurons reduces SEP amplitude but also reduces synaptic strength at the JON-GF synapse. Overall, these results suggest that En and Inv in JONs regulate both neuronal excitability and synaptic connectivity.
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