Evidence map›Paper›PMID 25164544›Full record

ArticleAngewandte Chemie (International ed. in English)2014

Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.

Anna M Rydzik, Ivanhoe K H Leung, Grazyna T Kochan, Michael A McDonough, Timothy D W Claridge, Christopher J Schofield

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Anna M RydzikDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA (UK).
Ivanhoe K H Leung
Grazyna T Kochan
Michael A McDonough
Timothy D W Claridge
Christopher J Schofield
University of Oxford · GB

Funding

Biotechnology and Biological Sciences Research CouncilBritish Heart FoundationCancer Research UKWellcome Trust
6 · The paper itself

Abstract

γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers.

Indexed as

BiocatalysisCarboxylic AcidsCarnitineCatalytic Domaingamma-Butyrobetaine DioxygenaseOxidation-ReductionPiperidinesStereoisomerismCarboxylic AcidsCarnitinegamma-Butyrobetaine DioxygenasepiperidinePiperidinesbiocatalysisC-H activationdesymmetrisationoxygenasesγ-butyrobetaine hydroxylase

Identifiers

PMID25164544
PMCPMC4497603
OpenAlexW2139512862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.