ArticleAnnals of neurology2014
White matter hyperintensities and hypobaric exposure.
Article in Annals of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Morphological brain changes in high-altitude careers and spaceflights: a systematic review and meta-analysis.BMC neurology · 2026Pooled it
- Occupational and domestic exposure associations with cerebral small vessel disease and vascular dementia: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Aerospace stressors and brain health in military aviators: a glymphatic-neurovascular framework.Frontiers in physiology · 2026Review
- The impact of occupational nonhypoxic hypobaria on cerebral function and integrity.Scientific reports · 2025Observational
- Acute Changes in Rat Tissue Gene Expression Following Exposure to Flight Relevant Hypobaria.Scientific data · 2025Article
- Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew.Brain sciences · 2024Article
- Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude.Communications biology · 2023Article
- Cerebral small-vessel disease at high altitude: A comparison of patients from plateau and plain.Frontiers in neurology · 2023Article
- Effects of acute high-altitude exposure on working memory: A functional near-infrared spectroscopy study.Brain and behavior · 2022Article
- Exposure to 16 h of normobaric hypoxia induces ionic edema in the healthy brain.Nature communications · 2021Article
- European position paper on the management of patients with patent foramen ovale. Part II - Decompression sickness, migraine, arterial deoxygenation syndromes and select high-risk clinical conditions.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2021Article
- High-altitude illnesses: Old stories and new insights into the pathophysiology, treatment and prevention.Sports medicine and health science · 2021Review
- Article
- Hypoxic Hypoxia and Brain Function in Military Aviation: Basic Physiology and Applied Perspectives.Frontiers in physiology · 2021Review
- Recommendations for traveling to altitude with neurological disorders.Journal of central nervous system disease · 2021Review
- White matter and hypoxic hypobaria in humans.Human brain mapping · 2019Article
- Reproducibility of quantitative structural and physiological MRI measurements.Brain and behavior · 2017Article
- Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude: A panel study.Human brain mapping · 2017Article
- Utilization of MRI for Cerebral White Matter Injury in a Hypobaric Swine Model-Validation of Technique.Military medicine · 2017Article
- Cortical Thickness of Native Tibetans in the Qinghai-Tibetan Plateau.AJNR. American journal of neuroradiology · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveDemonstrate that occupational exposure to nonhypoxic hypobaria is associated with subcortical white matter hyperintensities (WMHs) on fluid-attenuated inversion recovery magnetic resonance imaging (MRI).
methodsEighty-three altitude chamber personnel (PHY), 105 U-2 pilots (U2P), and 148 age- controlled and health-matched doctorate degree controls (DOC) underwent high-resolution MRI. Subcortical WMH burden was quantified as count and volume of subcortical WMH lesions after transformation of images to the Talairach atlas-based stereotactic frame.
resultsSubcortical WMHs were more prevalent in PHY (volume p = 0.011/count p = 0.019) and U2P (volume p < 0.001/count p < 0.001) when compared to DOC, whereas PHY were not significantly different than U2P.
interpretationThis study provides strong evidence that nonhypoxic hypobaric exposure may induce subcortical WMHs in a young, healthy population lacking other risk factors for WMHs and adds this occupational exposure to other environmentally related potential causes of WMHs. Ann Neurol 2014;76:719-726.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.