Evidence map›Paper›PMID 25164513›Full record

Trial reportJournal of cancer survivorship : research and practice2015

Blood pressure, salivary cortisol, and inflammatory cytokine outcomes in senior female cancer survivors enrolled in a tai chi chih randomized controlled trial.

Rebecca A Campo, Kathleen C Light, Kathleen O'Connor, Yoshio Nakamura, David Lipschitz, Paul C LaStayo, Lisa M Pappas, Kenneth M Boucher, Michael R Irwin, Harry R Hill and 3 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cancer survivorship : research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 14 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 14 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
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  6. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
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  10. The effects of Tai Chi on quality of life of cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
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  12. Ameliorative effects of Tai Chi on cancer-related fatigue: a meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  13. Qigong in cancer care: a systematic review and construct analysis of effective Qigong therapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
    Pooled it
  14. Use of Salivary Diurnal Cortisol as an Outcome Measure in Randomised Controlled Trials: a Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016
    Pooled it
  15. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Rebecca A CampoProgram on Integrative Medicine, Department of Physical Medicine & Rehabilitation, University of North Carolina at Chapel Hill, CB# 7200, Chapel Hill, NC, 27599-7200, USA, rebecca_campo@med.unc.edu.
Kathleen C Light
Kathleen O'Connor
Yoshio Nakamura
David Lipschitz
Paul C LaStayo
Lisa M Pappas
Kenneth M Boucher
Michael R Irwin
Harry R Hill
Thomas B Martins
Neeraj Agarwal
Anita Y Kinney
University of Utah · USHuntsman Cancer Institute · USUniversity of California, Los Angeles · USUniversity of New Mexico · USUniversity of North Carolina at Chapel Hill · US

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
Biobehavioral Effects of Tai Chi Chih Among Elderly Breast Cancer SurvivorsR21CA135250 · NCI · UNIVERSITY OF UTAH · PI KINNEY, ANITA Y. · 2009 to 2010
$530k
NCCIH NIH HHS T-32 AT00378NCI NIH HHS P30 CA042014NCI NIH HHS R21 CA135250NCI NIH HHS R21CA135250
6 · The paper itself

Abstract

purposeOlder cancer survivors are a vulnerable population due to an increased risk for chronic diseases (e.g., cardiovascular disease) compounded with treatment late-effects and declines in physical functioning. Therefore, interventions that reduce chronic disease risk factors (i.e., blood pressure, chronic inflammation, and cortisol) are important in this population. Tai chi chih (TCC) is a mind-body exercise associated with reductions in chronic disease risk factors, but has not been examined with older cancer survivors. In a feasibility randomized controlled trial of TCC, we examined secondary outcomes of blood pressure, salivary cortisol, and inflammatory cytokines (interleukin (IL)-6, IL-12, tumor necrosis factor-α, IL-10, IL-4) due to their implications in chronic diseases.

methodsSixty-three senior female cancer survivors (M age = 67 years, SD = 7.15) with physical functioning limitations (SF-12 physical functioning ≤80 or role-physical ≤72) were randomized to 12-weeks (60-min, three times a week) of TCC or Health Education control (HEC) classes. Resting blood pressure, 1-day salivary cortisol samples, and fasting plasma samples for cytokine multiplex assays were collected at baseline and 1-week post-intervention.

resultsControlling for baseline values, the TCC group had significantly lower systolic blood pressure (SBP, p = 0.002) and cortisol area-under-curve (AUC, p = 0.02) at post-intervention than the HEC group. There was no intervention effect on inflammatory cytokines (p's > 0.05).

conclusionsThis TCC feasibility trial was associated with significant reductions in SBP and cortisol AUC in senior female cancer survivors. Larger, definitive trials are needed to confirm these findings. IMPLICATIONS FOR CANCER SURVIVORS: Senior survivors' have an increased risk for chronic diseases; however, TCC interventions may help reduce associated risk factors.

Indexed as

AgedAged, 80 and overBlood PressureCytokinesFemaleHumansHydrocortisoneInflammationMiddle AgedNeoplasmsSurvivorsTai JiTreatment OutcomeCytokinesHydrocortisone

Identifiers

PMID25164513
PMCPMC4344390
OpenAlexW1985034779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.