Evidence map›Paper›PMID 25164464›Full record

ReviewSports medicine (Auckland, N.Z.)2014

A neuroinflammatory model for acute fatigue during exercise.

Nicole T Vargas, Frank Marino

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. The neurobiological markers of acute alcohol's subjective effects in humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nicole T VargasSchool of Human Movement Studies, Charles Sturt University, Bathurst, NSW, 2795, Australia, nvargas@csu.edu.au.
Frank Marino
Charles Sturt University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A common emotional human anomaly is the manifestation of fatigue which is felt as an overall symptom in times of sickness and disease, but also during and after exercise as a specific or general symptom of exhaustion and over exertion. The main culprit of fatigue during illness is thought to be the immune/inflammatory response that occurs as the body attempts to fight off the invading virus or bacteria. Numerous models of fatigue have been developed to help us understand its mechanisms in both disease and exercise, but none so far have specifically discussed the interactions between cytokine release during exercise and its effects on afferent feedback and processing of signals in the brain that might lead to sensations and feelings of fatigue. Therefore, this article examines the literature in a range of disciplines spanning exercise, disease, immunology, and neurology, in order to develop a neuroinflammatory model for acute fatigue during exercise, similar to that which we often feel during illness.

Indexed as

Afferent PathwaysBrainCytokinesExerciseFatigueHumansInflammationInterleukin-7Receptors, Interleukin-6Signal TransductionCytokinesInterleukin-7Receptors, Interleukin-6

Identifiers

PMID25164464
OpenAlexW2081590876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.