Evidence map›Paper›PMID 25164413›Full record

ReviewInternal and emergency medicine2014

Multimorbidity and polypharmacy in the elderly: lessons from REPOSI.

Pier Mannuccio Mannucci, Alessandro Nobili, REPOSI Investigators

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Internal and emergency medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03903484 (A Collaborative Intervention for Streamlining Medication Appropriateness and Deprescribing Within Integrated Health-Care Teams), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03903484 nacompletednot on this mapstarted 2019, after this paper: background citation

A Collaborative Intervention for Streamlining Medication Appropriateness and Deprescribing Within Integrated Health-Care Teams

TypeinterventionalSponsorNova Scotia Health AuthorityRan2019 to 2022Enrolled7ConditionsInappropriate Prescribing, Primary Health Care, PolypharmacyArmsDeprescribing toolbox and intervention
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  5. Polypharmacy and major adverse events in atrial fibrillation: observations from the AFFIRM trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2016
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Pier Mannuccio MannucciScientific Direction, IRCCS Foundation Maggiore Hospital Policlinico, Via Francesco Sforza 28, 20122, Milan, Italy, piermannuccio.mannucci@policlinico.mi.it.
Alessandro Nobili
REPOSI Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dramatic demographic changes that are occurring in the third millennium are modifying the mission of generalist professionals such as primary care physicians and internists. Multiple chronic diseases and the related prescription of multiple medications are becoming typical problems and present many challenges. Unfortunately, the available evidence regarding the efficacy of medications has been generated by clinical trials involving patients completely different from those currently admitted to internal medicine: much younger, affected by a single disease and managed in a highly controlled research environment. Because only registries can provide information on drug effectiveness in real-life conditions, REPOSI started in 2008 with the goal of acquiring data on elderly people acutely admitted to medical or geriatric hospital wards in Italy. The main goals of the registry were to evaluate drug prescription appropriateness, the relationship between multimorbidity/polypharmacy and such cogent outcomes as hospital mortality and re-hospitalization, and the identification of disease clusters that most often concomitantly occur in the elderly. The findings of 3-yearly REPOSI runs (2008, 2010, 2012) suggest the following pertinent tasks for the internist in order to optimally handle their elderly patients: the management of multiple medications, the need to become acquainted with geriatric multidimensional tools, the promotion and implementation of a multidisciplinary team approach to patient health and care and the corresponding involvement of patients and their relatives and caregivers. There is also a need for more research, tailored to the peculiar features of the multimorbid elderly patient.

Indexed as

ComorbidityGeriatricsPolypharmacyAgedAged, 80 and overFemaleHumansInternal MedicineItalyMaleRegistriesSocieties, Medical

Identifiers

PMID25164413

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.