ArticleScientific reports2014
Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Global quantitative proteome analysis of a multi-resistantFrontiers in microbiology · 2025Article
- Influence of the polysaccharide capsule on virulence and fitness ofFrontiers in microbiology · 2025Article
- Relevance of the Adjuvant Effect between Cellular Homeostasis and Resistance to Antibiotics in Gram-Negative Bacteria with Pathogenic Capacity: A Study ofAntibiotics (Basel, Switzerland) · 2024Review
- Combined effect of SAR-endolysin LysKpV475 with polymyxin B andMicrobiology (Reading, England) · 2024Article
- Microbial applications for sustainable space exploration beyond low Earth orbit.NPJ microgravity · 2023Review
- Review
- Phenotypic, genomic, and transcriptomic changes in an Acinetobacter baumannii strain after spaceflight in China's Tiangong-2 space laboratory.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- The Impacts of Microgravity on Bacterial Metabolism.Life (Basel, Switzerland) · 2022Review
- Growth Behavior and Transcriptome Profile Analysis ofPolish journal of microbiology · 2022Article
- Combined Impact of Magnetic Force and Spaceflight Conditions onInternational journal of molecular sciences · 2022Article
- The Space-Exposed Kombucha Microbial Community MemberFrontiers in microbiology · 2022Article
- Changes in Higher-Order Chromosomal Structure ofFrontiers in microbiology · 2022Article
- Database of space life investigations and bioinformatics of microbiology in extreme environments.Frontiers in microbiology · 2022Article
- Mechanotransduction in Prokaryotes: A Possible Mechanism of Spaceflight Adaptation.Life (Basel, Switzerland) · 2021Article
- Molecular repertoire of Deinococcus radiodurans after 1 year of exposure outside the International Space Station within the Tanpopo mission.Microbiome · 2020Article
- Prevention and Killing Efficacy of Carbapenem ResistantMaterials (Basel, Switzerland) · 2020Article
- Biofilms-Impacts on Human Health and Its Relevance to Space Travel.Microorganisms · 2020Review
- Molecular Mechanisms of Microbial Survivability in Outer Space: A Systems Biology Approach.Frontiers in microbiology · 2020Review
- Increased growth rate and amikacin resistance of Salmonella enteritidis after one-month spaceflight on China's Shenzhou-11 spacecraft.MicrobiologyOpen · 2019Article
- Decreased biofilm formation ability of Acinetobacter baumannii after spaceflight on China's Shenzhou 11 spacecraft.MicrobiologyOpen · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence and rapid spread of New Delhi Metallo-beta-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae strains has caused a great concern worldwide. To better understand the mechanisms underlying environmental adaptation of those highly drug-resistant K. pneumoniae strains, we took advantage of the China's Shenzhou 10 spacecraft mission to conduct comparative genomic and transcriptomic analysis of a NDM-1 K. pneumoniae strain (ATCC BAA-2146) being cultivated under different conditions. The samples were recovered from semisolid medium placed on the ground (D strain), in simulated space condition (M strain), or in Shenzhou 10 spacecraft (T strain) for analysis. Our data revealed multiple variations underlying pathogen adaptation into different environments in terms of changes in morphology, H2O2 tolerance and biofilm formation ability, genomic stability and regulation of metabolic pathways. Additionally, we found a few non-coding RNAs to be differentially regulated. The results are helpful for better understanding the adaptive mechanisms of drug-resistant bacterial pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.