ReviewCurrent psychiatry reports2014
Depression and cardiovascular disease: an update on how course of illness may influence risk.
Review in Current psychiatry reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Meta-analysis on inflammation and autonomic nervous system of coronary heart disease combined with depression.BMJ open · 2024Pooled it
- Meta-analysis of peripheral mean platelet volume in patients with mental disorders: Comparisons in depression, anxiety, bipolar disorder, and schizophrenia.Brain and behavior · 2023Pooled it
- Could Physical Activity Have any Role in Cardiovascular Disease Prevention in Prisoners? A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- One-day acceptance and commitment therapy (ACT) workshop improves anxiety but not vascular function or inflammation in adults with moderate to high anxiety levels in a randomized controlled trial.General hospital psychiatryTrial
- Self-harming behavior linked to earlier onset of cardiovascular disease in severe mental disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Exercise Intervention in Autonomic Function, Immunity, and Cardiovascular Health: A Precision Medicine Approach.Journal of cardiovascular development and disease · 2025Review
- Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study.Translational psychiatry · 2024Article
- Genome-Wide and Exome-Wide Association Study Identifies Genetic Underpinning of Comorbidity between Myocardial Infarction and Severe Mental Disorders.Biomedicines · 2024Article
- A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2024Article
- Comparison of Risk of Stroke in Patients With and Without Depression: A Systematic Review and Meta-Analysis.Cureus · 2024Review
- Causal relationship between depression and aging: a bidirectional two-sample Mendelian randomization study.Aging clinical and experimental research · 2023Article
- Gender differences in the association between cardiovascular diseases and major depressive disorder among older adults in India.Dialogues in health · 2023Article
- Network Structure of Comorbidity Patterns in U.S. Adults with Depression: A National Study Based on Data from the Behavioral Risk Factor Surveillance System.Depression research and treatment · 2023Article
- Exploring the relationship between vitamin D deficiency and comorbid heart disease in Americans with mood disorders: a cross-sectional nationwide study.Frontiers in psychiatry · 2023Article
- Understanding the effect of angina on general and dimensions of psychological distress: findings from understanding society.Frontiers in psychiatry · 2023Article
- Risk Factors for Dementia in Patients With Atrial Fibrillation.The American journal of cardiology · 2022Article
- Childhood-onset depression and arterial stiffness in young adulthood.Journal of psychosomatic research · 2021Article
- Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine APharmaceuticals (Basel, Switzerland) · 2021Article
- "GrimAge," an epigenetic predictor of mortality, is accelerated in major depressive disorder.Translational psychiatry · 2021Article
- Effect of depressive symptom and depressive disorder on glaucoma incidence in elderly.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Depression constitutes a novel and independent risk factor for cardiovascular disease, which despite extensive support in the literature has been underappreciated. While much of the evidence for depression as a risk factor for cardiovascular disease is based on studies following myocardial infarction, the elevated vascular risk conveyed by depression is not confined to periods following acute coronary syndromes. For that matter, the risk appears across mood disorders with evidence for even greater risk in bipolar disorder. This review summarizes the literature linking depressive disorders to cardiovascular mortality with a focus on how the course of illness of mood disorders may influence this risk. Mood disorders may influence risk over decades of illness in a dose-response to symptom burden, or the persistence of affective symptomatology. This may be mediated through changes in the activity of the autonomic nervous system, the hypothalamic-pituitary-adrenal axis, and inflammatory cytokines. Whether treatment of depression can mitigate this risk is not established although there are suggestions to support this contention, which could be better studied with more effective treatments of depression and larger standardized samples. Directions for future study of mechanisms and treatment are discussed. Regardless of causal mechanisms, persons with depressive disorders and other risk factors for vascular disease represent a neglected, high-risk group for cardiovascular events. In addition to the appropriate treatment for depression, screening and optimized management of traditional risk factors for cardiovascular diseases is necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.