ArticleBrain connectivity2014
Behavioral relevance of the dynamics of the functional brain connectome.
Article in Brain connectivity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Go with the (Blood) Flow: A Systematic Review on the Relationship Between Dynamic Functional Connectivity and Information Processing Speed.Neuropsychology review · 2026Pooled it
- Characterization of EEG Data Revealing Relationships With Cognitive and Motor Symptoms in Parkinson's Disease: A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS.Scientific reports · 2022Trial
- Dynamic and Static Resting-State Functional Connectivity of Canonical Networks in Military and Civilian Populations With Posttraumatic Stress Disorder and/or Mild Traumatic Brain Injury.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Flexible brain state engagement predicts cognitive control transdiagnostically.bioRxiv : the preprint server for biology · 2026Article
- Dual targeting of iNOS and Src tyrosine kinase as a superior therapeutic strategy against soman-induced long-term neurotoxicity: multimodal biomarker, imaging, and neurobehavioral outcome analyses.Acta neuropathologica communications · 2026Article
- Structural and dynamic functional controllability: shared variance between network control metrics limits attribution to distinct domains of intelligence.Frontiers in human neuroscience · 2026Article
- Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation.Alzheimer's research & therapy · 2025Article
- Changes on Cognition and Brain Network Temporal Variability After Pediatric Neurosurgery.Neurosurgery · 2025Article
- Topology Assisted Clustering of Temporal fMRI Brain Networks With Use-Case in Mitigating Non-Neural Multi-Site Variability.IEEE access : practical innovations, open solutions · 2025Article
- Dynamic functional network connectivity and its association with lipid metabolism in Alzheimer's disease.CNS neuroscience & therapeutics · 2024Article
- Stacking models of brain dynamics to improve prediction of subject traits in fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Dynamicity of brain network organization & their community architecture as characterizing features for classification of common mental disorders from whole-brain connectome.Translational psychiatry · 2024Article
- Abnormal dynamic functional connectivity and topological properties of cerebellar network in male obstructive sleep apnea.CNS neuroscience & therapeutics · 2024Article
- Higher general intelligence is associated with stable, efficient, and typical dynamic functional brain connectivity patterns.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Static and dynamic brain functional connectivity patterns in patients with unilateral moderate-to-severe asymptomatic carotid stenosis.Frontiers in aging neuroscience · 2024Article
- Age-related unstable transient states and imbalanced activation proportion of brain networks in people with autism spectrum disorder: A resting-state fMRI study using coactivation pattern analyses.Network neuroscience (Cambridge, Mass.) · 2024Article
- Static and dynamic functional connectomes represent largely similar information.bioRxiv : the preprint server for biology · 2023Article
- Static and dynamic fMRI-derived functional connectomes represent largely similar information.Network neuroscience (Cambridge, Mass.) · 2023Article
- State-switching and high-order spatiotemporal organization of dynamic functional connectivity are disrupted by Alzheimer's disease.Network neuroscience (Cambridge, Mass.) · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
While many previous studies assumed the functional connectivity (FC) between brain regions to be stationary, recent studies have demonstrated that FC dynamically varies across time. However, two challenges have limited the interpretability of dynamic FC information. First, a principled framework for selecting the temporal extent of the window used to examine the dynamics is lacking and this has resulted in ad-hoc selections of window lengths and subsequent divergent results. Second, it is unclear whether there is any behavioral relevance to the dynamics of the functional connectome in addition to that obtained from conventional static FC (SFC). In this work, we address these challenges by first proposing a principled framework for selecting the extent of the temporal windows in a dynamic and data-driven fashion based on statistical tests of the stationarity of time series. Further, we propose a method involving three levels of clustering-across space, time, and subjects-which allow for group-level inferences of the dynamics. Next, using a large resting-state functional magnetic resonance imaging and behavioral dataset from the Human Connectome Project, we demonstrate that metrics derived from dynamic FC can explain more than twice the variance in 75 behaviors across different domains (alertness, cognition, emotion, and personality traits) as compared with SFC in healthy individuals. Further, we found that individuals with brain networks exhibiting greater dynamics performed more favorably in behavioral tasks. This indicates that the ease with which brain regions engage or disengage may provide potential biomarkers for disorders involving altered neural circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.