Evidence map›Paper›PMID 25163434›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015

Effect of muscle mass on toxicity and survival in patients with colon cancer undergoing adjuvant chemotherapy.

Hee-Won Jung, Jin Won Kim, Ji-Yeon Kim, Sun-Wook Kim, Hyun Kyung Yang, Joon Woo Lee, Keun-Wook Lee, Duck-Woo Kim, Sung-Bum Kang, Kwang-Il Kim and 2 more

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 115 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04567459 naunknown statusnot on this mapstarted 2021, after this paper: background citation

The Effect of Nutrition for the Colorectal Cancer Patients Receiving Chemotherapy-randomized Controlled Study

TypeinterventionalSponsorChang Gung Memorial HospitalRan2021 to 2021Enrolled100ConditionsColorectal CancerArmsPremium Amino Acids
NCT07255001 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Monitoring Physical Function Changes in Patients With Pancreatic Ductal Adenocarcinoma: Potential for Better Understanding of Treatment Trajectory and Survival

TypeinterventionalSponsorBritish Columbia Cancer AgencyRan2025 to 2027Enrolled50ConditionsPancreatic Ductal Adenocarcinoma (PDAC), Hand Grip StrengthArmsHand grip strength assessments using a dynamometer
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hee-Won JungDivision of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173 beon-gil, Bundang-gu, Seongnam, 463-707, South Korea.
Jin Won Kim
Ji-Yeon Kim
Sun-Wook Kim
Hyun Kyung Yang
Joon Woo Lee
Keun-Wook Lee
Duck-Woo Kim
Sung-Bum Kang
Kwang-Il Kim
Cheol-Ho Kim
Jee Hyun Kim

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to elucidate the effect of decreased muscle mass on the toxicity and survival of patients with colon cancer treated with adjuvant chemotherapy after surgery.

methodsWe reviewed the data of 229 consecutive patients with stage III colon cancer who received adjuvant oxaliplatin, 5-fluorouracil, and leucovorin chemotherapy at a single center between 2003 and 2010. Baseline muscle mass was assessed by measuring the cross-sectional area of the psoas muscle at the level of the fourth lumbar vertebra on computed tomography images. Effects of muscle mass on toxicity of chemotherapy and survival were assessed.

resultsThe median age of the 229 patients was 61 years (range, 28-80) and 134 (58.5 %) were men. The mean psoas muscle mass index (PI, psoas muscle area divided by height(2) [mm(2)/m(2)]) was 548.3. A 1 SD decrement in the PI was associated with an increase in all grade 3-4 toxicities in univariate (OR = 1.69, 95 % CI = 1.18-2.27) and multivariate (OR = 1.56, 95 % CI = 1.05-2.38) analyses. In univariate analysis, the PI was not associated with overall survival. However, multivariate analysis showed that a 1 SD decrement in the PI increased the hazard of overall mortality by 85 % (HR = 1.85, 95 % CI = 1.10-3.13). This effect of the PI on mortality was maintained in subgroup analyses, especially in older and obese patients.

conclusionsDecreased muscle mass was associated with increased risk of grade 3-4 toxicity and poor prognosis in patients with stage III colon cancer.

Indexed as

AdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBody CompositionChemotherapy, AdjuvantColonic NeoplasmsFemaleFluorouracilHumansLeucovorinMaleMiddle AgedMuscle, SkeletalObesityOrganoplatinum CompoundsFluorouracilLeucovorinOrganoplatinum CompoundsOxaliplatin

Identifiers

PMID25163434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.