ArticlePloS one2014
Structural and functional brain changes beyond visual system in patients with advanced glaucoma.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Application of advanced diffusion MRI based tractometry of the visual pathway in glaucoma: a systematic review.Frontiers in neuroscience · 2025Pooled it
- Advanced Morphological and Functional Magnetic Resonance Techniques in Glaucoma.BioMed research international · 2015Pooled it
- Glaucoma Rehabilitation Using ElectricAI Transcranial Stimulation (GREAT)-Optimizing Stimulation Protocol for Vision Enhancement Using an RCT.Translational vision science & technology · 2024Trial
- Cognitive impairment in glaucoma.Indian journal of ophthalmology · 2026Review
- Neurophysiological Evidence of Visual Cortical Alterations in Mild Primary Glaucoma: A Resting-State EEG Microstate Study.Brain topography · 2026Article
- Neurodegeneration in Glaucoma: Microstructural Magnetic Resonance Imaging Evidence Within and Beyond the Visual Pathway.Investigative ophthalmology & visual science · 2026Article
- How blindness shapes personality: a neuro-ecological account.Frontiers in neuroscience · 2026Article
- Beyond the Eye: Glaucoma and the Brain.Brain sciences · 2025Review
- Change in Mechanical Property of Rat Brain Suffering from Chronic High Intraocular Pressure.Bioengineering (Basel, Switzerland) · 2025Article
- Neuroprotection beyond intraocular pressure: game changer or quiet addiction.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Review
- The Connectivity of the Resting Brain in Primary Open-Angle Glaucoma: A Systematic Review.Biomedicines · 2025Review
- Glaucoma and brain functional networks: a bidirectional Mendelian randomisation study.BMJ open ophthalmology · 2025Article
- Beyond vision loss: the impact of glaucoma on the brain.Frontiers in cell and developmental biology · 2025Review
- Topological Organization of the Brain Network in Patients with Primary Angle-closure Glaucoma Through Graph Theory Analysis.Brain topography · 2024Article
- Gaze behavior in open-angle glaucoma patients during visuo-cognitive-motor tasks: a cross-sectional study.Scientific reports · 2024Article
- Contrast Discrimination and Global Form Perception in Primary Open-Angle Glaucoma and Primary Angle-Closure Glaucoma.Investigative ophthalmology & visual science · 2024Article
- Extraction of three-dimensional shapes in glaucoma patients in response to monocular depth cues.Japanese journal of ophthalmology · 2024Observational
- Elevated Intraocular Pressure Moderated Brain Morphometry in High-tension Glaucoma: a Structural MRI Study.Clinical neuroradiology · 2024Article
- Arterial spin labeling reveals disordered cerebral perfusion and cerebral blood flow-based functional connectivity in primary open-angle glaucoma.Brain imaging and behavior · 2024Article
- Diffusion tensor imaging of optic neuropathies: a narrative review.Quantitative imaging in medicine and surgery · 2024Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to test the hypothesis that in primary open angle glaucoma (POAG), an important cause of irreversible blindness, a spreading of neurodegeneration occurs through the brain, we performed multimodal MRI and subsequent whole-brain explorative voxelwise analyses in 13 advanced POAG patients and 12 age-matched normal controls (NC). Altered integrity (decreased fractional anisotropy or increased diffusivities) of white matter (WM) tracts was found not only along the visual pathway of POAG but also in nonvisual WM tracts (superior longitudinal fascicle, anterior thalamic radiation, corticospinal tract, middle cerebellar peduncle). POAG patients also showed brain atrophy in both visual cortex and other distant grey matter (GM) regions (frontoparietal cortex, hippocampi and cerebellar cortex), decreased functional connectivity (FC) in visual, working memory and dorsal attention networks and increased FC in visual and executive networks. In POAG, abnormalities in structure and FC within and outside visual system correlated with visual field parameters in the poorer performing eyes, thus emphasizing their clinical relevance. Altogether, this represents evidence that a vision disorder such as POAG can be considered a widespread neurodegenerative condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.