ArticleAnalytical chemistry2014
High-resolution low-field molecular magnetic resonance imaging of hyperpolarized liquids.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Magnetic resonance imaging.Science advances · 2026Review
- Open-Source Multinuclear Low-Field Preclinical MRI Scanner.NMR in biomedicine · 2026Article
- Upscaling the Hyperpolarization Sample Volume of an Automated Hydrogenative Parahydrogen-Induced Polarizer.ACS measurement science au · 2025Article
- Novel non‑metal‑based contrast agents for MR imaging: Emerging approaches and clinical perspectives (Review).International journal of oncology · 2025Review
- Low-Cost Purpose-Built Ultra-Low-Field NMR Spectrometer.Analytical chemistry · 2024Article
- Toward Next-Generation Molecular Imaging with a Clinical Low-Field (0.064 T) Point-of-Care MRI Scanner.Analytical chemistry · 2024Article
- Molecules, Up Your Spins!Molecules (Basel, Switzerland) · 2024Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Proton-Only Sensing of Hyperpolarized [1,2-ACS sensors · 2022Article
- Clinical-Scale Production of Nearly Pure (>98.5%) Parahydrogen and Quantification by Benchtop NMR Spectroscopy.Analytical chemistry · 2021Article
- Hydrogenative-PHIP polarized metabolites for biological studies.Magma (New York, N.Y.) · 2021Review
- Signal-enhanced real-time magnetic resonance of enzymatic reactions at millitesla fields.Chemical science · 2020Article
- Parahydrogen-Induced Polarization of Diethyl Ether Anesthetic.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- A versatile synthetic route to the preparation ofJournal of labelled compounds & radiopharmaceuticals · 2019Article
- Low-Concentration Measurements of Nuclear Spin-Induced Optical Rotation Using SABRE Hyperpolarization.The journal of physical chemistry letters · 2019Article
- SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange.Scientific reports · 2019Article
- Hyperpolarizing Concentrated MetronidazoleChemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Article
- Parahydrogen-Based Hyperpolarization for Biomedicine.Angewandte Chemie (International ed. in English) · 2018Review
- Spin-Lattice Relaxation of Hyperpolarized Metronidazole in Signal Amplification by Reversible Exchange in Micro-Tesla Fields.The journal of physical chemistry. C, Nanomaterials and interfaces · 2018Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
We demonstrate the feasibility of microscale molecular imaging using hyperpolarized proton and carbon-13 MRI contrast media and low-field (47.5 mT) preclinical scale (38 mm i.d.) 2D magnetic resonance imaging (MRI). Hyperpolarized proton images with 94 × 94 μm(2) spatial resolution and hyperpolarized carbon-13 images with 250 × 250 μm(2) in-plane spatial resolution were recorded in 4-8 s (largely limited by the electronics response), surpassing the in-plane spatial resolution (i.e., pixel size) achievable with micro-positron emission tomography (PET). These hyperpolarized proton and (13)C images were recorded using large imaging matrices of up to 256 × 256 pixels and relatively large fields of view of up to 6.4 × 6.4 cm(2). (13)C images were recorded using hyperpolarized 1-(13)C-succinate-d2 (30 mM in water, %P(13C) = 25.8 ± 5.1% (when produced) and %P(13C) = 14.2 ± 0.7% (when imaged), T1 = 74 ± 3 s), and proton images were recorded using (1)H hyperpolarized pyridine (100 mM in methanol-d4, %P(H) = 0.1 ± 0.02% (when imaged), T1 = 11 ± 0.1 s). Both contrast agents were hyperpolarized using parahydrogen (>90% para-fraction) in an automated 5.75 mT parahydrogen induced polarization (PHIP) hyperpolarizer. A magnetized path was demonstrated for successful transportation of a (13)C hyperpolarized contrast agent (1-(13)C-succinate-d2, sensitive to fast depolarization when at the Earth's magnetic field) from the PHIP polarizer to the 47.5 mT low-field MRI. While future polarizing and low-field MRI hardware and imaging sequence developments can further improve the low-field detection sensitivity, the current results demonstrate that microscale molecular imaging in vivo is already feasible at low (<50 mT) fields and potentially at low (~1 mM) metabolite concentrations.
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Registered trials
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