ArticlePloS one2014
Induction of salivary proteins modifies measures of both orosensory and postingestive feedback during exposure to a tannic acid diet.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 44 citations in OpenAlex.
- Cranberry Polyphenol Extract (CPE) Oral Rinse Improves Salivary Microbiome in 6-n-Propylthiouracil (PROP) Non-Tasters and Palatability of Aronia Juice.International journal of molecular sciences · 2026Article
- Functional bitter taste signaling and stimulus intensity influence diet-induced salivary protein upregulation.Appetite · 2026Article
- Effects of Tannic Acid on Immune Function and Gut Microbiota in Brandt's Voles (Microorganisms · 2026Article
- Article
- Bitter and Sweet Diets Alter Taste Response and Alcohol Consumption Behavior in Mice.Nutrients · 2025Article
- Salivary response of Geoffroy's spider monkeys (PeerJ · 2025Article
- Patterns of ingestion of rats during chronic oral administration of lithium chloride.Physiology & behavior · 2024Article
- Salivary proteins rescue within-session suppression and conditioned avoidance in response to an intragastric quinine infusion.Physiology & behavior · 2024Article
- TRPM4 and PLCβ3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCβ3 is not needed for taste-driven licking for glucose.Chemical senses · 2024Article
- The role of saliva in taste and food intake.Physiology & behavior · 2023Review
- Mediterranean Diet: The Role of Phenolic Compounds from Aromatic Plant Foods.Foods (Basel, Switzerland) · 2023Review
- Salivary flow and turbidity development inconsistently associated with lower taste intensity of vegetables and juices.Food quality and preference · 2023Article
- Article
- Influence of tannic acid concentration on the physicochemical characteristics of saliva of spider monkeys (PeerJ · 2022Article
- Associations among fatty food sensations and saliva's emulsifying properties.Chemical senses · 2022Article
- Repeated exposure to epigallocatechin gallate solution or water alters bitterness intensity and salivary protein profile.Physiology & behavior · 2021Article
- Effects of Tannic Acid on Antioxidant Activity and Ovarian Development in Adolescent and Adult Female Brandt's Voles.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Observational
- Addition of chocolate milk to diet corresponds to protein concentration changes in human saliva.Physiology & behavior · 2020Article
- Altering salivary protein profile can decrease aversive oromotor responding to quinine in rats.Physiology & behavior · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
There are hundreds of proteins in saliva. Although it has long been hypothesized that these proteins modulate taste by interacting with taste receptors or taste stimuli, the functional impact of these proteins on feeding remains relatively unexplored. We have developed a new technique for saliva collection that does not interfere with daily behavioral testing and allows us to explore the relationship between feeding behavior and salivary protein expression. First, we monitored the alterations in salivary protein expression while simultaneously monitoring the animals' feeding behavior and meal patterns on a custom control diet or on the same diet mixed with 3% tannic acid. We demonstrated that six protein bands increased in density with dietary tannic acid exposure. Several of these bands were significantly correlated with behaviors thought to represent both orosensory and postingestive signaling. In a follow-up experiment, unconditioned licking to 0.01-3% tannic acid solutions was measured during a brief-access taste test before and after exposure to the tannic acid diet. In this experiment, rats with salivary proteins upregulated found the tannin solution less aversive (i.e., licked more) than those in the control condition. These data suggest a role for salivary proteins in mediating changes in both orosensory and postingestive feedback.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.