Evidence map›Paper›PMID 25162255›Full record

ArticleObstetrics and gynecology2014

Factors associated with gastroschisis outcomes.

Rachael T Overcash, Daniel A DeUgarte, Megan L Stephenson, Rachel M Gutkin, Mary E Norton, Sima Parmar, Manuel Porto, Francis R Poulain, David B Schrimmer, University of California Fetal Consortium*

Open access · greenAbstract read
In one paragraph

Article in Obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 112 citations in OpenAlex.

  1. Article
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  7. Prenatal ultrasound markers for prediction of complex gastroschisis-single-center retrospective cohort study.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  8. A multicenter matched-cohort analysis of gastroschisis outcomes in infants born before 32 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
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  12. Review
  13. Short and Medium-term Outcomes of Omphalocele and Gastroschisis: A Survey from a Tertiary Center.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
    Article
  14. Interval growth across gestation in pregnancies with fetal gastroschisis.American journal of obstetrics & gynecology MFM · 2021
    Article
  15. Article
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  18. Gastroschisis: A State-of-the-Art Review.Children (Basel, Switzerland) · 2020
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Rachael T OvercashDivision of Maternal Fetal Medicine, Department of Reproductive Medicine, University of California San Diego, San Diego, the Division of Pediatric Surgery, Department of Surgery and the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California Los Angeles, Los Angeles, the Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, University of California Irvine, Irvine, the Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California San Francisco, San Francisco, and the Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology and the Division of Neonatology, Department of Pediatrics, University of California Davis, Davis, California.
Daniel A DeUgarte
Megan L Stephenson
Rachel M Gutkin
Mary E Norton
Sima Parmar
Manuel Porto
Francis R Poulain
David B Schrimmer
University of California Fetal Consortium*
U.S. National Science Foundation · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124
6 · The paper itself

Abstract

objectiveTo identify perinatal variables associated with adverse outcomes in neonates prenatally diagnosed with gastroschisis.

methodsA retrospective review was conducted of all inborn pregnancies complicated by gastroschisis within the five institutions of the University of California Fetal Consortium from 2007 to 2012. The primary outcome was a composite adverse neonatal outcome comprising death, reoperation, gastrostomy, and necrotizing enterocolitis. Variables collected included antenatal ultrasound findings, maternal smoking or drug use, gestational age at delivery, preterm labor, elective delivery, mode of delivery, and birth weight. Univariate and multivariate analysis was used to assess factors associated with adverse outcomes. We also evaluated the association of preterm delivery with neonatal outcomes such as total parenteral nutrition cholestasis and length of stay.

resultsThere were 191 neonates born with gastroschisis in University of California Fetal Consortium institutions at a mean gestational age of 36 3/7±1.8 weeks. Within the cohort, 27 (14%) had one or more major adverse outcomes, including three deaths (1.6%). Early gestational age at delivery was the only variable identified as a significant predictor of adverse outcomes on both univariate and multivariate analysis (odds ratio 1.4, 95% confidence interval 1.1-1.8 for each earlier week of gestation). Total parenteral nutrition cholestasis was significantly more common in neonates delivered at less than 37 weeks of gestation (38/115 [33%] compared with 11/76 [15%]; P<.001).

conclusionIn this contemporary cohort, earlier gestational age at delivery is associated with adverse neonatal outcomes in neonates with gastroschisis. Other variables, such as antenatal ultrasound findings and mode of delivery, did not predict adverse neonatal outcomes.

Indexed as

Delivery, ObstetricGastroschisisGestational AgePregnancy ComplicationsAdultCaliforniaEnterocolitis, NecrotizingFemaleGastrostomyHumansInfant, NewbornLength of StayMultivariate AnalysisObstetric Labor, PrematureOutcome Assessment, Health CarePregnancy

Identifiers

PMID25162255
PMCPMC4147679
OpenAlexW2069229599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.