ReviewFrontiers in cellular and infection microbiology2014
Chromosomal islands of Streptococcus pyogenes and related streptococci: molecular switches for survival and virulence.
Review in Frontiers in cellular and infection microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Genetic and functional characterization of the natural transformation system inMicrobiology (Reading, England) · 2026Article
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- Streptococcus anginosus of the urogenital tract: evidence of the same strain across anatomical sites of the same females.BMC genomics · 2025Article
- Interactions and evolutionary relationships among bacterial mobile genetic elements.Nature reviews. Microbiology · 2025Review
- A comprehensive analysis of antimicrobial resistance of clinicalJAC-antimicrobial resistance · 2025Article
- Expanding the genetic toolbox for the obligate human pathogenFrontiers in bioengineering and biotechnology · 2024Article
- TheJournal of bacteriology · 2023Article
- In silico characterization of cysteine-stabilized αβ defensins from neglected unicellular microeukaryotes.BMC microbiology · 2023Article
- The Life Cycle Transitions of Temperate Phages: Regulating Factors and Potential Ecological Implications.Viruses · 2022Review
- Phage satellites and their emerging applications in biotechnology.FEMS microbiology reviews · 2021Review
- Article
- Cryptic prophages within aMicrobial genomics · 2021Article
- Characterization of Clinical and CarrierViruses · 2020Article
- Development and Application of a Prophage Integrase Typing Scheme for Group BFrontiers in microbiology · 2020Article
- The Bacteriophages ofMicrobiology spectrum · 2019Review
- Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus.BMC microbiology · 2019Article
- Staphylococcal pathogenicity islands-movers and shakers in the genomic firmament.Current opinion in microbiology · 2017Review
- Phage-inducible islands in the Gram-positive cocci.The ISME journal · 2017Article
- Comparative Genome Analysis of the Daptomycin-Resistant Streptococcus anginosus Strain J4206 Associated with Breakthrough Bacteremia.Genome biology and evolution · 2016Article
- Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity.Journal of bacteriology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Streptococcus pyogenes is a significant pathogen of humans, annually causing over 700,000,000 infections and 500,000 deaths. Virulence in S. pyogenes is closely linked to mobile genetic elements like phages and chromosomal islands (CI). S. pyogenes phage-like chromosomal islands (SpyCI) confer a complex mutator phenotype on their host. SpyCI integrate into the 5' end of DNA mismatch repair (MMR) gene mutL, which also disrupts downstream operon genes lmrP, ruvA, and tag. During early logarithmic growth, SpyCI excise from the bacterial chromosome and replicate as episomes, relieving the mutator phenotype. As growth slows and the cells enter stationary phase, SpyCI reintegrate into the chromosome, again silencing the MMR operon. This system creates a unique growth-dependent and reversible mutator phenotype. Additional CI using the identical attachment site in mutL have been identified in related species, including Streptococcus dysgalactiae subsp. equisimilis, Streptococcus anginosus, Streptococcus intermedius, Streptococcus parauberis, and Streptococcus canis. These CI have small genomes, which range from 13 to 20 kB, conserved integrase and DNA replication genes, and no identifiable genes encoding capsid proteins. SpyCI may employ a helper phage for packaging and dissemination in a fashion similar to the Staphylococcus aureus pathogenicity islands (SaPI). Outside of the core replication and integration genes, SpyCI and related CI show considerable diversity with the presence of many indels that may contribute to the host cell phenotype or fitness. SpyCI are a subset of a larger family of streptococcal CI who potentially regulate the expression of other host genes. The biological and phylogenetic analysis of streptococcal chromosomal islands provides important clues as to how these chromosomal islands help S. pyogenes and other streptococcal species persist in human populations in spite of antibiotic therapy and immune challenges.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.