ArticleNeuroImage. Clinical2014
Intersession reliability of fMRI activation for heat pain and motor tasks.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03354585 (Brain Mechanisms Supporting Mindfulness-based Chronic Pain Relief), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain Mechanisms Supporting Mindfulness-based Chronic Pain Relief
Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Neural effects of cathodal transcranial direct current stimulation over left supramarginal gyrus on cognitive empathy for pain.Cognitive, affective & behavioral neuroscience · 2026Article
- Reliability of task-based fMRI in the dorsal horn of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Dissociation between individual differences in self-reported pain intensity and underlying fMRI brain activation.Nature communications · 2022Article
- Effect sizes and test-retest reliability of the fMRI-based neurologic pain signature.NeuroImage · 2022Article
- Evaluation of a personalized functional near infra-red optical tomography workflow using maximum entropy on the mean.Human brain mapping · 2021Article
- Noxious pressure stimulation demonstrates robust, reliable estimates of brain activity and self-reported pain.NeuroImage · 2020Article
- The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI.Molecular psychiatry · 2019Article
- Exploring the potential role of mesocorticolimbic circuitry in motivation for and adherence to chronic pain self-management interventions.Neuroscience and biobehavioral reviews · 2019Review
- Reward and aversion processing in patients with post-traumatic stress disorder: functional neuroimaging with visual and thermal stimuli.Translational psychiatry · 2018Article
- Altered Signaling in the Descending Pain-modulatory System after Short-Term Infusion of the μ-Opioid Agonist Remifentanil.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Intraclass correlation: Improved modeling approaches and applications for neuroimaging.Human brain mapping · 2018Article
- Brodmann area 10: Collating, integrating and high level processing of nociception and pain.Progress in neurobiology · 2018Review
- Using prerecorded hemodynamic response functions in detecting prefrontal pain response: a functional near-infrared spectroscopy study.Neurophotonics · 2018Article
- Parietal operculum and motor cortex activities predict motor recovery in moderate to severe stroke.NeuroImage. Clinical · 2017Article
- Between- and within-site variability of fMRI localizations.Human brain mapping · 2016Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
As the practice of conducting longitudinal fMRI studies to assess mechanisms of pain-reducing interventions becomes more common, there is a great need to assess the test-retest reliability of the pain-related BOLD fMRI signal across repeated sessions. This study quantitatively evaluated the reliability of heat pain-related BOLD fMRI brain responses in healthy volunteers across 3 sessions conducted on separate days using two measures: (1) intraclass correlation coefficients (ICC) calculated based on signal amplitude and (2) spatial overlap. The ICC analysis of pain-related BOLD fMRI responses showed fair-to-moderate intersession reliability in brain areas regarded as part of the cortical pain network. Areas with the highest intersession reliability based on the ICC analysis included the anterior midcingulate cortex, anterior insula, and second somatosensory cortex. Areas with the lowest intersession reliability based on the ICC analysis also showed low spatial reliability; these regions included pregenual anterior cingulate cortex, primary somatosensory cortex, and posterior insula. Thus, this study found regional differences in pain-related BOLD fMRI response reliability, which may provide useful information to guide longitudinal pain studies. A simple motor task (finger-thumb opposition) was performed by the same subjects in the same sessions as the painful heat stimuli were delivered. Intersession reliability of fMRI activation in cortical motor areas was comparable to previously published findings for both spatial overlap and ICC measures, providing support for the validity of the analytical approach used to assess intersession reliability of pain-related fMRI activation. A secondary finding of this study is that the use of standard ICC alone as a measure of reliability may not be sufficient, as the underlying variance structure of an fMRI dataset can result in inappropriately high ICC values; a method to eliminate these false positive results was used in this study and is recommended for future studies of test-retest reliability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.