ArticleNeuroImage. Clinical2014
Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: a case study.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04347590 (Impact of Continuous Glucose Monitoring on Cerebral Oxygenation in Preterm Infants), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Continuous Glucose Monitoring on Cerebral Oxygenation in Preterm Infants (the Babyglucolight Trial)
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Optical Monitoring in Neonatal Seizures.Cells · 2022Pooled it
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Disrupted functional connectivity during stroke recovery revealed via bedside optical neuroimaging.Neurophotonics · 2026Article
- Continuous Wave-Diffuse Optical Tomography (CW-DOT) in Human Brain Mapping: A Review.Sensors (Basel, Switzerland) · 2025Review
- Intracranial functional near-infrared spectroscopy: an animal feasibility study.Frontiers in medical technology · 2025Article
- Decellularization of various tissues and organs through chemical methods.Tissue & cell · 2024Review
- Investigating the effect of limited spectral information on NIRS-derived changes in hemoglobin and cytochrome-c-oxidase concentration with a diffusion-based model.Biomedical optics express · 2024Article
- Developing customized NIRS-EEG for infant sleep research: methodological considerations.Neurophotonics · 2023Article
- Longitudinal fNIRS and EEG metrics of habituation and novelty detection are correlated in 1-18-month-old infants.NeuroImage · 2023Article
- Functional near infrared spectroscopy for brain functional connectivity analysis: A graph theoretic approach.Heliyon · 2023Article
- Broadband-NIRS System Identifies Epileptic Focus in a Child with Focal Cortical Dysplasia-A Case Study.Metabolites · 2022Article
- Brain temperature monitoring in newborn infants: Current methodologies and prospects.Frontiers in pediatrics · 2022Review
- Neonatal NIRS monitoring: recommendations for data capture and review of analytics.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Construction and validation of a database of head models for functional imaging of the neonatal brain.Human brain mapping · 2021Article
- Design and validation of a mechanically flexible and ultra-lightweight high-density diffuse optical tomography system for functional neuroimaging of newborns.Neurophotonics · 2021Article
- Role of Optical Neuromonitoring in Neonatal Encephalopathy-Current State and Recent Advances.Frontiers in pediatrics · 2021Review
- Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers.Sensors (Basel, Switzerland) · 2020Article
- High-density diffuse optical tomography for imaging human brain function.The Review of scientific instruments · 2019Article
- Neonatal brain injury and aberrant connectivity.NeuroImage · 2019Review
- Measurement of Neurovascular Coupling in Neonates.Frontiers in physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Seizures in the newborn brain represent a major challenge to neonatal medicine. Neonatal seizures are poorly classified, under-diagnosed, difficult to treat and are associated with poor neurodevelopmental outcome. Video-EEG is the current gold-standard approach for seizure detection and monitoring. Interpreting neonatal EEG requires expertise and the impact of seizures on the developing brain remains poorly understood. In this case study we present the first ever images of the haemodynamic impact of seizures on the human infant brain, obtained using simultaneous diffuse optical tomography (DOT) and video-EEG with whole-scalp coverage. Seven discrete periods of ictal electrographic activity were observed during a 60 minute recording of an infant with hypoxic-ischaemic encephalopathy. The resulting DOT images show a remarkably consistent, high-amplitude, biphasic pattern of changes in cortical blood volume and oxygenation in response to each electrographic event. While there is spatial variation across the cortex, the dominant haemodynamic response to seizure activity consists of an initial increase in cortical blood volume prior to a large and extended decrease typically lasting several minutes. This case study demonstrates the wealth of physiologically and clinically relevant information that DOT-EEG techniques can yield. The consistency and scale of the haemodynamic responses observed here also suggest that DOT-EEG has the potential to provide improved detection of neonatal seizures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.