ArticleBeilstein journal of organic chemistry2014
Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA2DNA triplexes.
Article in Beilstein journal of organic chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Novel nicotinoid structures for covalent modification of wood: an environmentally friendly way for its protection against insects.RSC advances · 2020Article
- Antibacterial Peptide Nucleic Acids-Facts and Perspectives.Molecules (Basel, Switzerland) · 2020Review
- Fluorogenic PNA probes.Beilstein journal of organic chemistry · 2018Review
- Pyrene-nucleobase conjugates: synthesis, oligonucleotide binding and confocal bioimaging studies.Beilstein journal of organic chemistry · 2017Article
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Authors and funding
4 authors.
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Abstract
Pyrene derivatives can be incorporated into nucleic acid analogs in order to obtain switchable probes or supramolecular architectures. In this paper, peptide nucleic acids (PNAs) containing 1 to 3 1-pyreneacetic acid units (PNA1-6) with a sequence with prevalence of pyrimidine bases, complementary to cystic fibrosis W1282X point mutation were synthesized. These compounds showed sequence-selective switch-on of pyrene excimer emission in the presence of target DNA, due to PNA2DNA triplex formation, with stability depending on the number and positioning of the pyrene units along the chain. An increase in triplex stability and a very high mismatch-selectivity, derived from combined stacking and base-pairing interactions, were found for PNA2, bearing two distant pyrene units.
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