ReviewARYA atherosclerosis2014
The association of genetic variations with sensitivity of blood pressure to dietary salt: A narrative literature review.
Review in ARYA atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Macronutrients and the FTO gene expression in hypothalamus; a systematic review of experimental studies.Indian heart journalPooled it
- Relationship Between Salt Consumption and Blood Pressure in Sub-Saharan African Population Living in an Urban Setting: The Case of a Group of Cameroonians.International journal of hypertension · 2025Article
- Effects of a high-salt diet on MAP and expression levels of renal ENaCs and aquaporins in SHR.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Examining the Potential Effect of a Salt Sensitivity Biomarker in Korean American Immigrants: A Pilot Study.Journal of immigrant and minority health · 2022Article
- The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.Physiological genomics · 2022Review
- Candidate Gene Polymorphisms Influence the Susceptibility to Salt Sensitivity of Blood Pressure in a Han Chinese Population: Risk Factors as Mediators.Frontiers in genetics · 2021Article
- Angiotensin receptor blockade with Losartan attenuates pressor response to handgrip contraction and enhances natriuresis in salt loaded hypertensive subjects: a quasi-experimental study among Nigerian adults.The Pan African medical journal · 2019Article
- A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer.BioMed research international · 2018Review
- Excessive dietary sodium intake and elevated blood pressure: a review of current prevention and management strategies and the emerging role of pharmaconutrigenetics.BMJ nutrition, prevention & health · 2018Review
- Some dietary factors can modulate the effect of the zinc transporters 8 polymorphism on the risk of metabolic syndrome.Scientific reports · 2017Article
- Review of studies on the fat mass and obesity-associated (FTO) gene interactions with environmental factors affecting on obesity and its impact on lifestyle interventions.ARYA atherosclerosis · 2016Review
- Modeling health gains and cost savings for ten dietary salt reduction targets.Nutrition journal · 2016Article
- Personalized Therapy of Hypertension: the Past and the Future.Current hypertension reports · 2016Review
- Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2015Article
- Molecular targets of antihypertensive peptides: understanding the mechanisms of action based on the pathophysiology of hypertension.International journal of molecular sciences · 2014Review
- Ethnic disparities among food sources of energy and nutrients of public health concern and nutrients to limit in adults in the United States: NHANES 2003-2006.Food & nutrition research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salt sensitivity of blood pressure (BP) is an independent risk factor for cardiovascular morbidity. Up to 50% of patients with essential hypertension are salt-sensitive, as manifested by a rise in BP with salt intake. Several genetic variations have been identified as being associated with salt sensitivity. The present study aimed to review the evidence on the effect of gene polymorphisms on the salt sensitivity of BP. We searched in PubMed website from 1990 to 2011, with the use of following keywords: "hypertension, dietary salt, polymorphisms, and blood pressure". The effect of sodium intake on BP differed by genotype at the genes of the renin-angiotensin system, aldosterone synthase, cytochrome p450 3A, epithelial sodium channel genes, genes of sympathetic nervous system, β-3 subunit of G-protein, alpha-adducin, endothelial nitric oxide synthase, Kallikrein-Kinin system. These approaches suggest that these polymorphisms may be potentially useful genetic markers of BP response to dietary salt. There is evidence that genetic predisposition modulates the BP response to diet. Therefore, diet and nutrition can mitigate or enhance the effects of genetic predisposition. Increasing our knowledge of this relationship can lead to individualized treatment and increased understanding of hypertension.
Indexed as
Identifiers
25161689PMC4144382W1859375226What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.