ArticleFrontiers in pharmacology2014
Measurement of airway function using invasive and non-invasive methods in mild and severe models for allergic airway inflammation in mice.
Article in Frontiers in pharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
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- Art an 3 as a candidate recombinant antigen for Artemisia pollen immunotherapy: comparative efficacy and mechanistic insights.Frontiers in medicine · 2026Article
- Clostridium leptum attenuates allergic airway inflammation via tDC‒Treg axis activation in a murine model of gut dysbiosis-associated asthma.Scientific reports · 2025Article
- Post-burn Lung Inflammation Is Associated With Induction of Pulmonary Cathelicidin-related Antimicrobial Peptide and S100a8 in Mice.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Efficacy of EA575 as an Antitussive and Mucoactive Agent in Preclinical In Vivo Models.Biomedicines · 2025Article
- Advanced Age Worsens Respiratory Function and Pulmonary Inflammation After Burn Injury and This Correlates With Changes in the Fecal Microbiome in Mice.Journal of burn care & research : official publication of the American Burn Association · 2025Article
- Chitooligosaccharides suppress airway inflammation, fibrosis, and mucus hypersecretion in a house dust mite-induced allergy model.Frontiers in allergy · 2025Article
- A synbiotic mixture ofFrontiers in nutrition · 2024Article
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- Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung AfterFrontiers in immunology · 2022Article
- Reinvestigating the Coughing Rat Model of Pertussis To UnderstandInfection and immunity · 2021Article
- Short and dysfunctional telomeres protect from allergen-induced airway inflammation.Aging cell · 2021Article
- Persistent Airway Hyperresponsiveness Following Recovery from Infection with Pneumonia Virus of Mice.Viruses · 2021Article
- The Effects of Maternal Smoking on Pregnancy and Offspring: Possible Role for EGF?Frontiers in cell and developmental biology · 2021Article
- Systematic Characterization of the Group 2 House Dust Mite Allergen inFrontiers in cellular and infection microbiology · 2021Article
- Differentially expressed circular RNAs in a murine asthma model.Molecular medicine reports · 2020Article
- Evidence for Asthma in the Lungs of Mice Inoculated with Different Doses ofThe American journal of tropical medicine and hygiene · 2020Article
- Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis.PloS one · 2020Article
- Glucagon-Like Peptide 1 and Atrial Natriuretic Peptide in a Female Mouse Model of Obstructive Pulmonary Disease.Journal of the Endocrine Society · 2020Article
- Endomorphin-2- and Neurotensin- Based Chimeric Peptide Attenuates Airway Inflammation in Mouse Model of Nonallergic Asthma.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study a direct comparison was made between non-invasive and non-ventilated unrestrained whole body plethysmography (Penh) (conscious animals) and the invasive ventilated lung resistance (RL) method (anesthetized animals) in both mild and severe allergic airway inflammation models. Mild inflammation was induced by intraperitoneal sensitization and aerosols of ovalbumin. Severe inflammation was induced by intraperitoneal sensitization using trinitrophenyl-ovalbumin, followed by intranasal challenges with IgE-allergen complexes. A significant increase in airway responsiveness to methacholine was observed in the mild inflammation group when RL was measured. Significant changes in both RL and Penh were observed in the severe inflammation groups. There was a significant increase in the number of inflammatory cells in the Broncho-Alveolar Lavage Fluid (BALF) in both the mild and severe inflammation animals. The enforced ventilation of the animals during the RL measurement further increased the number of cells in the BALF. IL-2 and RANTES levels in the BALF were higher in the severe inflammation groups compared to the mild inflammation groups. Penh gave only reliable measurements during severe airway inflammation. Measuring RL gave consistent results in both mild and severe allergic airway inflammation models however, ventilation induced an additional cell influx into the airways.
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