ArticleFrontiers in human neuroscience2014
Air pollution and detrimental effects on children's brain. The need for a multidisciplinary approach to the issue complexity and challenges.
Article in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure.Environmental health perspectives · 2017Pooled it
- A randomised clinical trial to evaluate the safety, fit, comfort of a novel N95 mask in children.Scientific reports · 2019Trial
- The association of depressive symptoms in children with indoor and outdoor short-term exposure to particulate matter.BMC public health · 2026Article
- Interaction between air pollution and diet on cognitive function in schoolchildren.BMC public health · 2026Article
- A review of the impact of structural racism on lived experiences of adolescents of African descent: Implications for development, brain structure, and health.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The Impact of Air Pollution and Obesity on Cognitive Decline and Risk of Alzheimer's Disease.International journal of molecular sciences · 2025Review
- The Epidemiological and Toxicological Intersection of Air Pollution and Dementia.Reviews of environmental contamination and toxicology · 2025Review
- Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024Review
- Ambient air pollution and the risk of violence in primary and secondary school settings: a cross-sectional study.Injury epidemiology · 2024Article
- General and Specific Factors of Environmental Stress and Their Associations With Brain Structure and Dimensions of Psychopathology.Biological psychiatry global open science · 2023Article
- Prenatal exposure to ambient air pollution is associated with neurodevelopmental outcomes at 2 years of age.Environmental health : a global access science source · 2023Article
- The Berlin-Brandenburg Air Study-A Methodological Study Paper of a Natural Experiment Investigating Health Effects Related to Changes in Airport-Related Exposures.International journal of public health · 2023Article
- Prenatal PM2.5 exposure in the second and third trimesters predicts neurocognitive performance at age 9-10 years: A cohort study of Mexico City children.Environmental research · 2021Article
- Air Pollution during Pregnancy and Childhood Autism Spectrum Disorder in Taiwan.International journal of environmental research and public health · 2021Article
- Inequalities in Exposure to Ambient Air Neurotoxicants and Disparities in Markers of Neurodevelopment in Children by Maternal Nativity Status.International journal of environmental research and public health · 2021Article
- The Role of Behavioral Ecotoxicology in Environmental Protection.Environmental science & technology · 2021Article
- Defining and Intervening on Cumulative Environmental Neurodevelopmental Risks: Introducing a Complex Systems Approach.Environmental health perspectives · 2021Article
- Air Pollution: A Neglected Risk Factor for Dementia in Latin America and the Caribbean.Frontiers in neurology · 2021Article
- Does living close to a petrochemical complex increase the adverse psychological effects of the COVID-19 lockdown?PloS one · 2021Article
- Prenatal PMNeurotoxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Millions of children in polluted cities are showing brain detrimental effects. Urban children exhibit brain structural and volumetric abnormalities, systemic inflammation, olfactory, auditory, vestibular and cognitive deficits v low-pollution controls. Neuroinflammation and blood-brain-barrier (BBB) breakdown target the olfactory bulb, prefrontal cortex and brainstem, but are diffusely present throughout the brain. Urban adolescent Apolipoprotein E4 carriers significantly accelerate Alzheimer pathology. Neurocognitive effects of air pollution are substantial, apparent across all populations, and potentially clinically relevant as early evidence of evolving neurodegenerative changes. The diffuse nature of the neuroinflammation and neurodegeneration forces to employ a weight of evidence approach incorporating current clinical, cognitive, neurophysiological, radiological and epidemiological research. Pediatric air pollution research requires extensive multidisciplinary collaborations to accomplish a critical goal: to protect exposed children through multidimensional interventions having both broad impact and reach. Protecting children and teens from neural effects of air pollution should be of pressing importance for public health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.