ReviewFrontiers in neuroanatomy2014
Pyramidal cell development: postnatal spinogenesis, dendritic growth, axon growth, and electrophysiology.
Review in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
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Who cites it
113 citing papers in PubMed.
- Cellular correlates of cortical thinning throughout the lifespan.Scientific reports · 2020Trial
- Postnatal maturation of putamen microstructure accompanies topographic white matter connectivity and altered circuits in autism.bioRxiv : the preprint server for biology · 2026Article
- A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.Nature neuroscience · 2026Article
- The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.Annual review of neuroscience · 2026Review
- Protracted Functional and Structural Reorganization of Human Prefrontal Cortex Supports Lateralized Category Geometries.bioRxiv : the preprint server for biology · 2026Article
- Postnatal Development of Pyramidal Neurons Excitability and Synaptic Inputs in Mouse Gustatory Cortical Circuits.eNeuro · 2026Article
- Hierarchical microstructural tissue growth of the gray and white matter of human visual cortex during the first year of life.Brain structure & function · 2026Article
- How do infant brains fold? Sulcal deepening is linked to development of sulcal span, thickness, curvature, and microstructure.Communications biology · 2026Article
- Connectome-based symptom mapping and in silico related gene expression in children with autism and/or attention-deficit/hyperactivity disorder.Molecular psychiatry · 2026Article
- Postnatal Development of the Perirhinal and Parahippocampal Cortices: A Stereological Study in Macaque Monkeys.The Journal of comparative neurology · 2026Article
- The effective connectome over a century of human life.Communications biology · 2025Article
- Postnatal development of pyramidal neurons excitability and synaptic inputs in mouse gustatory cortical circuits.bioRxiv : the preprint server for biology · 2025Article
- Electrophysiology and morphology of human cortical supragranular pyramidal cells in a wide age range.eLife · 2025Article
- Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex.Journal of neurophysiology · 2025Article
- Visuospatial computations vary by category and stream and continue to develop in adolescence.bioRxiv : the preprint server for biology · 2025Article
- Electrophysiology and Morphology of Human Cortical Supragranular Pyramidal Cells in a Wide Age Range.bioRxiv : the preprint server for biology · 2025Article
- Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress.eNeuro · 2025Article
- Development of Higher-Level Vision: A Network Perspective.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Signatures of hierarchical temporal processing in the mouse visual system.PLoS computational biology · 2024Article
- Population-wide cerebellar growth models of children and adolescents.Nature communications · 2024Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we review recent findings related to postnatal spinogenesis, dendritic and axon growth, pruning and electrophysiology of neocortical pyramidal cells in the developing primate brain. Pyramidal cells in sensory, association and executive cortex grow dendrites, spines and axons at different rates, and vary in the degree of pruning. Of particular note is the fact that pyramidal cells in primary visual area (V1) prune more spines than they grow during postnatal development, whereas those in inferotemporal (TEO and TE) and granular prefrontal cortex (gPFC; Brodmann's area 12) grow more than they prune. Moreover, pyramidal cells in TEO, TE and the gPFC continue to grow larger dendritic territories from birth into adulthood, replete with spines, whereas those in V1 become smaller during this time. The developmental profile of intrinsic axons also varies between cortical areas: those in V1, for example, undergo an early proliferation followed by pruning and local consolidation into adulthood, whereas those in area TE tend to establish their territory and consolidate it into adulthood with little pruning. We correlate the anatomical findings with the electrophysiological properties of cells in the different cortical areas, including membrane time constant, depolarizing sag, duration of individual action potentials, and spike-frequency adaptation. All of the electrophysiological variables ramped up before 7 months of age in V1, but continued to ramp up over a protracted period of time in area TE. These data suggest that the anatomical and electrophysiological profiles of pyramidal cells vary among cortical areas at birth, and continue to diverge into adulthood. Moreover, the data reveal that the "use it or lose it" notion of synaptic reinforcement may speak to only part of the story, "use it but you still might lose it" may be just as prevalent in the cerebral cortex.
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