ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2014
A prospective study on Adverse Drug Reactions of antibiotics in a tertiary care hospital.
Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Pharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions.Pharmacological reviews · 2026Review
- Magnitude and Predictors of Antimicrobial Use-Related Drug Problems in Geriatric Inpatients: Evaluation of Pharmacist Interventions.Current drug safety · 2026Article
- Resistance, Ineffectiveness, and Off-Label Use Related to Cephalosporins from the Reserve Group-A Pharmacovigilance Signal Detection Study on EudraVigilance Database.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Causality, severity, seriousness, and preventability of adverse drug reactions: A retrospective analysis.Journal of family medicine and primary care · 2025Article
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome with Multiple Drugs (Leflunomide and Cefuroxime): A Case Report.Current drug safety · 2025Article
- Article
- Implementation of the pharmacovigilance database in the usage of antibiotics in a tertiary care hospital: A pilot study.Health science reports · 2024Article
- Incidence and Severity of Adverse Drug Reactions in Medical Intensive Care Unit.Current drug safety · 2024Article
- Understanding the Effects of Iatrogenic Management on Population Health: A Medical Innovation Perspective.China CDC weekly · 2023Article
- Incidence and Economic Burden of Adverse Drug Reactions in Hospitalization: A Prospective Study in Korea.Journal of Korean medical science · 2023Article
- Article
- A prospective study to evaluate antimicrobial prescribing pattern among admitted patients in hilly Himalayan region of northern India.Journal of family medicine and primary care · 2021Article
- Drug Therapy Problems and Predictors Among Patients Admitted to Medical Wards of Dilla University Referral Hospital, South Ethiopia: A Case of Antimicrobials.Infection and drug resistance · 2020Article
- Inferring ADR causality by predicting the Naranjo Score from Clinical Notes.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020Article
- Clinical Judgement Study using Question Answering from Electronic Health Records.Proceedings of machine learning research · 2019Article
- Adverse Effects of Fluoroquinolones: A Retrospective Cohort Study in a South Indian Tertiary Healthcare Facility.Antibiotics (Basel, Switzerland) · 2019Article
- Long-term prescribing of nitrofurantoin for urinary tract infections (UTI) in veterans with spinal cord injury (SCI).The journal of spinal cord medicine · 2019Article
- Knowledge and Practice of Pharmacists toward Antimicrobial Stewardship in Pakistan.Pharmacy (Basel, Switzerland) · 2018Article
- Causality and preventability assessment of adverse drug events of antibiotics among inpatients having different lengths of hospital stay: a multicenter, cross-sectional study in Lahore, Pakistan.BMC pharmacology & toxicology · 2018Observational
- Evaluation of Reported Adverse Drug Reactions in Antibiotic Usage: A Retrospective Study From a Tertiary Care Hospital, Malaysia.Frontiers in pharmacology · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse reactions are the recognized hazards of drug therapy and they can occur with any class of drugs and many studies revealed that the incidence is more in case of antibiotics. The main aim of this study was to detect and analyze Adverse Drug Reactions of antibiotics in inpatients of a tertiary care hospital. A prospective spontaneous reporting study by active and passive methods was carried out for a period of six months. A total of 49 ADRs were reported during the study period with male predominance (53.06%) and geriatric age group. More number of ADRs was from General Medicine and Pediatric departments in which the most affected organ systems were the GIT (38.77%) and the skin (30.61%). The antibiotic classes mostly accounted were cephalosporins (34.69%) followed by fluoroquinolones and others in which type A reactions were more compared to type B and 59.18% of them were predictable. The severity assessment revealed that most of them were moderate (63.26%) followed by mild and severe reactions. Of the reported reactions, 55.10% were definitely preventable and causality assessment was done which showed that 71.42% of the reactions were probable, possible (18.36%), definite (10.20%) and no reactions were unlikely. The study concluded that Adverse Drug Reactions to antibiotics are common and some of them resulted in increased healthcare cost due to the need of some interventions and increased length of hospital stay. The health system should promote the spontaneous reporting of Adverse Drug Reactions to antibiotics, proper documentation and periodic reporting to regional pharmacovigilance centers to ensure drug safety.
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