ArticleAsian journal of transfusion science2014
Clinical significance of antibody specificities to M, N and Lewis blood group system.
Article in Asian journal of transfusion science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 21 citations in OpenAlex.
- Global Prevalence and Specificity of Red Blood Cell Antibodies in Blood Donors: A Systematic Review and Meta-Analysis.Diseases (Basel, Switzerland) · 2026Review
- New insights into the sensitivity of Immulab reagent red blood cells compared to Bio-Rad, Grifols and QuidelOrtho.BMC research notes · 2025Article
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- A possible case of a haemolytic transfusion reaction caused by anti-Le(a) antibody.Blood transfusion = Trasfusione del sangue · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe clinically significant antibodies are those active at 37°C and/or by the indirect antiglobulin test. Most of the published literature refers to antibodies of Lewis blood group system to be insignificant, whereas antibodies to M and N blood groups are associated with variable clinical significance.
aimsThe aim of this study is to find the frequency and clinical significance of antibodies to M, N and Lewis blood group systems. SETTINGS AND
designThe study was carried out retrospectively from January 2009 to December 2012. MATERIALS AND
methodsAntibody screening was performed by solid phase red cell adherence (SPRCA) technique using four cell screening panel on a fully automated platform GALILEO (Immucor Inc. USA). In case of a positive antibody screen, antibody identification was performed using SPRCA (GALILEO, Immucor Inc. USA).
resultsA total of 49,077 red cell antibody screens were performed and a total of 427 identifications of red cell antibodies were carried out. A total of 304 specific antibodies were detected: 8.22% of antibodies were of anti-M specificity and 2.96% were of anti-N specificity. Majority (84%) of anti-M and 77.78% of anti-N were of Immunoglobulin G (IgG) class reacting at 37°C. 1.31% of the antibodies were directed against Lewis system antigens of which 0.65% were anti-Lea and 0.65% were anti-Leb. Half of the Lewis system antibodies, i.e., 1 each of anti-Lea and anti-Leb were of IgG class.
conclusionOur study highlights the importance of detecting the thermal amplitude of antibodies with variable clinical significance especially if both IgG and IgM types of antibodies are associated with it so as to establish their clinical significance.
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