ArticleHuman brain mapping2015
Brain size, sex, and the aging brain.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cross-Sectional Volumes and Trajectories of the Human Brain, Gray Matter, White Matter and Cerebrospinal Fluid in 9473 Typically Aging Adults.Neuroinformatics · 2021Pooled it
- Pooled it
- Enhancing reproducibility in neuroimaging with containerized archival.Brain imaging and behavior · 2026Article
- Estimating Accelerated Retinal Decline in Mental Health Disorders Through Normative Modeling.Schizophrenia bulletin · 2026Article
- Automated Surface-Based Segmentation of Deep Gray Matter Regions Based on Diffusion Tensor Images Reveals Unique Age Trajectories Over the Healthy Lifespan.NMR in biomedicine · 2026Article
- Hematopoietic Stem Cell Transplant and Brain Volume Changes in Adults With Sickle Cell Disease.Neurology · 2026Article
- 3D-Printable, Honeycomb-Inspired Tissue-Like Bioelectrodes for Patient-Specific Neural Interface.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Linking changes in sulcal morphometry to cognitive development from childhood to adolescence.Communications biology · 2026Article
- Relationships Between Lateral Ventricle Size, Cerebrospinal Fluid Dynamics, and Aqueductal Resistance in Young Healthy Adults.Journal of magnetic resonance imaging : JMRI · 2026Article
- Amygdala volume is not associated with MRI-based markers of early cardiovascular disease.Insights into imaging · 2026Article
- Sex differences in global metrics of brain size across the lifespan.Frontiers in neuroscience · 2026Article
- Longitudinal development of sex differences in the limbic system is associated with age, puberty and mental health.Communications biology · 2025Article
- Conventional and Advanced Magnetic Resonance Imaging Biomarkers of Multiple Sclerosis in the Brain.Cureus · 2025Review
- Age at type 1 diabetes onset does not influence attained brain volume.BMC endocrine disorders · 2025Article
- Disentangling the effect of sex from brain size on brain organization and cognitive functioning.GeroScience · 2025Article
- Abnormalities in cerebellar subregions' volume and cerebellocerebral structural covariance in autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2025Article
- Normative trajectories of RImaging neuroscience (Cambridge, Mass.) · 2025Article
- Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency.Journal of endocrinological investigation · 2024Article
- Sex Differences in Human Brain Structure at Birth.Biology of sex differences · 2024Article
- Increases in regional brain volume across two native South American male populations.GeroScience · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was conducted to examine the statistical influence of brain size on cortical, subcortical, and cerebellar compartmental volumes. This brain size influence was especially studied to delineate interactions with Sex and Age. Here, we studied 856 healthy subjects of which 533 are classified as young and 323 as old. Using an automated segmentation procedure cortical (gray and white matter [GM and WM] including the corpus callosum), cerebellar (GM and WM), and subcortical (thalamus, putamen, pallidum, caudatus, hippocampus, amygdala, and accumbens) volumes were measured and subjected to statistical analyses. These analyses revealed that brain size and age exert substantial statistical influences on nearly all compartmental volumes. Analyzing the raw compartmental volumes replicated the frequently reported Sex differences in compartmental volumes with men showing larger volumes. However, when statistically controlling for brain size Sex differences and Sex × Age interactions practically disappear. Thus, brain size is more important than Sex in explaining interindividual differences in compartmental volumes. The influence of brain size is discussed in the context of an allometric scaling of the compartmental volumes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.