ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Spreading depolarization-induced adenosine accumulation reflects metabolic status in vitro and in vivo.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Involvement of adenosine signaling pathway in migraine pathophysiology: a systematic review of preclinical studies.The journal of headache and pain · 2022Pooled it
- Spreading Depolarization Induces a Transient Potentiation of Excitatory Synaptic Transmission.Neuroscience · 2024Article
- Trauma in Neonatal Acute Brain Slices Alters Calcium and Network Dynamics and Causes Calpain-Mediated Cell Death.eNeuro · 2024Article
- Spreading depolarizations pose critical energy challenges in acute brain injury.Journal of neurochemistry · 2024Review
- Ketamine improves neuronal recovery following spreading depolarization in peri-infarct tissues.Journal of neurochemistry · 2024Article
- Synaptic ZnNeurobiology of disease · 2024Article
- Synaptic ZnbioRxiv : the preprint server for biology · 2023Article
- Repetitive spreading depolarization induces gene expression changes related to synaptic plasticity and neuroprotective pathways.Frontiers in cellular neuroscience · 2023Article
- The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention.Neurocritical care · 2022Review
- Microglia Modulate Cortical Spreading Depolarizations After Ischemic Stroke: A Narrative Review.Neurocritical care · 2022Review
- Memantine Improves Recovery After Spreading Depolarization in Brain Slices and can be Considered for Future Clinical Trials.Neurocritical care · 2021Article
- Brain Energy Deficit as a Source of Oxidative Stress in Migraine: A Molecular Basis for Migraine Susceptibility.Neurochemical research · 2021Review
- The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy.Frontiers in neuroscience · 2021Review
- Purines: From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury.Neuroscience bulletin · 2020Review
- Acute sleep deprivation enhances susceptibility to the migraine substrate cortical spreading depolarization.The journal of headache and pain · 2020Article
- Ketamine reduces deleterious consequences of spreading depolarizations.Experimental neurology · 2018Article
- Blockade and knock-out of CALHM1 channels attenuate ischemic brain damage.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Article
- Evidence that adenosine contributes to Leao's spreading depression in vivo.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- The Role of Adenosine Signaling in Headache: A Review.Brain sciences · 2017Review
- Mechanisms of Neuronal Silencing After Cortical Spreading Depression.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Spreading depolarization (SD), a pathologic feature of migraine, stroke and traumatic brain injury, is a propagating depolarization of neurons and glia causing profound metabolic demand. Adenosine, the low-energy metabolite of ATP, has been shown to be elevated after SD in brain slices and under conditions likely to trigger SD in vivo. The relationship between metabolic status and adenosine accumulation after SD was tested here, in brain slices and in vivo. In brain slices, metabolic impairment (assessed by nicotinamide adenine dinucleotide (phosphate) autofluorescence and O2 availability) was associated with prolonged extracellular direct current (DC) shifts indicating delayed repolarization, and increased adenosine accumulation. In vivo, adenosine accumulation was observed after SD even in otherwise healthy mice. As in brain slices, in vivo adenosine accumulation correlated with DC shift duration and increased when DC shifts were prolonged by metabolic impairment (i.e., hypoglycemia or middle cerebral artery occlusion). A striking pattern of adenosine dynamics was observed during focal ischemic stroke, with nearly all the observed adenosine signals in the periinfarct region occurring in association with SDs. These findings suggest that adenosine accumulation could serve as a biomarker of SD incidence and severity, in a range of clinical conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.