Evidence map›Paper›PMID 25160563›Full record

Trial reportBMC cardiovascular disorders2014

Blood pressure values and depression in hypertensive individuals at high cardiovascular risk.

Cilia Mejia-Lancheros, Ramón Estruch, Miguel Angel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, José Manuel Santos, Montse Fitó, Fernando Arós and 6 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in BMC cardiovascular disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Observational
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 1 country.

Cilia Mejia-Lancheros
Ramón Estruch
Miguel Angel Martínez-González
Jordi Salas-Salvadó
Dolores Corella
Enrique Gómez-Gracia
Miquel Fiol
José Manuel Santos
Montse Fitó
Fernando Arós
Lluis Serra-Majem
Xavier Pintó
Josep Basora
José Vicente Sorlí
Miguel-Angel MuñozDepartment of Paediatrics, Obstetrics, Gynaecology and Preventive Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. mamunoz.bcn.ics@gencat.cat.
PREDIMED Study Investigators
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · ESInstituto de Salud Carlos III · ESUniversitat Autònoma de Barcelona · ESBellvitge University Hospital · ESHospital del Mar Research Institute · ESHospital Universitario Araba · ESResearch Institute of Health Sciences · ESUniversidad de Navarra · ESUniversidad Rovira i Virgili · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension and depression are both important risk factors for cardiovascular diseases. Nevertheless, the association of blood pressure on and depression has not been completely established. This study aims to analyze whether depression may influence the control of blood pressure in hypertensive individuals at high cardiovascular risk.

methodsCross-sectional study, embedded within the PREDIMED clinical trial, of 5954 hypertensive patients with high cardiovascular risk factor profiles. The relationship between blood pressure control and depression was analyzed. A multivariate analysis (logistic and log-linear regression), adjusting for potential confounders (socio-demographic factors, body mass index, lifestyle, diabetes, dyslipidemia, and antihypertensive treatment), was performed.

resultsDepressive patients, with and without antidepressant treatment, had better blood pressure control (OR: 1.28, CI 95%: 1.06-1.55, and OR: 1.30, CI 95%: 1.03-1.65, respectively) than non-depressive ones. Regarding blood pressure levels, systolic blood pressure values (mmHg) were found to be lower in both treated and untreated depressive patients (Log coefficient Beta: -1.59, 95% CI: -0.50 to -2.69 and Log coefficient Beta: -3.49, 95% CI: -2.10 to -4.87, respectively).

conclusionsAmong hypertensive patients at high cardiovascular risk, the control of blood pressure was better in those diagnosed with depression.

trial registrationUnique identifier: ISRCTN35739639.

Indexed as

AgedAged, 80 and overAntidepressive AgentsAntihypertensive AgentsBlood PressureChi-Square DistributionCross-Sectional StudiesDepressionHumansHypertensionLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioAntidepressive AgentsAntihypertensive Agents

Identifiers

PMID25160563
PMCPMC4243424
OpenAlexW2150015527

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.