Observational studyPediatric neurology2014
White matter injury in newborns with congenital heart disease: a diffusion tensor imaging study.
Observational study in Pediatric neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Neurodevelopmental care across pediatric critical care settings: toward brain-focused critical care.European journal of pediatrics · 2026Review
- Intraoperative sodium range affects white matter microstructure in neonatal congenital heart disease.International journal of cardiology. Congenital heart disease · 2026Article
- Disrupted White Matter Topology Organization in Preschool Children with Tetralogy of Fallot.Brain and behavior · 2024Article
- The cumulative impact of clinical risk on brain networks and associations with executive function impairments in adolescents with congenital heart disease.Human brain mapping · 2024Article
- Association between subcortical nuclei volume changes and cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: a cross-sectional study.Italian journal of pediatrics · 2024Article
- Postnatal Brain Trajectories and Maternal Intelligence Predict Childhood Outcomes in Complex CHD.Journal of clinical medicine · 2024Article
- Perioperative Neuromonitoring in Children with Congenital Heart Disease.Neurocritical care · 2024Review
- Individual Assessment of Perioperative Brain Growth Trajectories in Infants With Congenital Heart Disease: Correlation With Clinical and Surgical Risk Factors.Journal of the American Heart Association · 2023Article
- Impact of Infant Thoracic Non-cardiac Perioperative Critical Care on Homotopic-Like Corpus Callosum and Forebrain Sub-regional Volumes.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Fetal brain issues in congenital heart disease.Translational pediatrics · 2021Review
- Brain MRI Radiomics Analysis of School-Aged Children with Tetralogy of Fallot.Computational and mathematical methods in medicine · 2021Article
- Neurological complications after pediatric cardiac surgery.The cardiothoracic surgeon · 2021Article
- Altered white matter microstructure is related to cognition in adults with congenital heart disease.Brain communications · 2021Article
- Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry.Scientific reports · 2020Article
- Article
- Changes in Cortical Thickness Are Associated With Cognitive Ability in Postoperative School-Aged Children With Tetralogy of Fallot.Frontiers in neurology · 2020Article
- Delayed maturation of the structural brain connectome in neonates with congenital heart disease.Brain communications · 2020Article
- Altered brain diffusion tensor imaging indices in adolescents with the Fontan palliation.Neuroradiology · 2019Article
- White matter injury in term neonates with congenital heart diseases: Topology & comparison with preterm newborns.NeuroImage · 2019Article
- Structural network topology correlates of microstructural brain dysmaturation in term infants with congenital heart disease.Human brain mapping · 2018Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundBrain injury is observed on cranial magnetic resonance imaging preoperatively in up to 50% of newborns with congenital heart disease. Newer imaging techniques such as diffusion tensor imaging provide sensitive measures of the white matter integrity. The objective of this study was to evaluate the diffusion tensor imaging analysis technique of tract-based spatial statistics in newborns with congenital heart disease.
methodsTerm newborns with congenital heart disease who would require surgery at less than 1 month of age were prospectively enrolled (n = 19). Infants underwent preoperative and postoperative brain magnetic resonance imaging with diffusion tensor imaging. Tract-based spatial statistics, an objective whole-brain diffusion tensor imaging analysis technique, was used to determine differences in white matter fractional anisotropy between infant groups. Term control infants were also compared with congenital heart disease infants. Postmenstrual age was equivalent between congenital heart disease infant groups and between congenital heart disease and control infants.
resultsTen infants had preoperative brain injury, either infarct or white matter injury, by conventional brain magnetic resonance imaging. The technique of tract-based spatial statistics showed significantly lower fractional anisotropy (P < 0.05, corrected) in multiple major white matter tracts in the infants with preoperative brain injury compared with infants without preoperative brain injury. Fractional anisotropy values increased in the white matter tracts from the preoperative to the postoperative brain magnetic resonance imaging correlating with brain maturation. Control infants had higher fractional anisotropy in multiple white matter tracts compared with infants with congenital heart disease.
conclusionTract-based spatial statistics is a valuable diffusion tensor imaging analysis technique that may have better sensitivity in detecting white matter injury compared with conventional brain magnetic resonance imaging in term newborns with congenital heart disease.
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