ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2015
Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Virtual Reality Distraction for Reducing Pain and Anxiety During Percutaneous Cardiovascular Interventions: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Standards for the management of cancer-related pain across Europe-A position paper from the EFIC Task Force on Cancer Pain.European journal of pain (London, England) · 2019Guideline
- Article
- Persistent opioid use is associated with a shorter myeloma survival.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Trajectory, interactions, and predictors of higher symptom burden during induction therapy for multiple myeloma.Journal of patient-reported outcomes · 2024Article
- Virtual Reality for Pain and Anxiety Management in Cardiac Surgery and Interventional Cardiology.JACC. Advances · 2024Review
- The role of surgery in relieving calcified shunt site-related pain in patients with functioning VP shunt.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Review
- Article
- Characterizing Pain Experiences: African American Patients With Multiple Myeloma Taking Around-the-Clock Opioids.Clinical journal of oncology nursing · 2020Article
- 'It is a journey of discovery': living with myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Utilization of pain medications and its effect on quality of life, health care utilization and associated costs in individuals with chronic back pain.Journal of pain research · 2019Article
- The Effect of Acupressure on Pain in Cancer Patients With Bone Metastasis: A Nonrandomized Controlled Trial.Integrative cancer therapies · 2018Article
- Article
- Towards a better understanding of the relationship between side effects of analgesia and quality of life in patients with multiple myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Tapentadol prolonged release for patients with multiple myeloma suffering from moderate-to-severe cancer pain due to bone disease.Journal of pain research · 2015Article
- Cancer pain for the 21st century: stepping off the ladder, stepping up to new challenges.British journal of pain · 2014Article
- A Qualitative Study of the Pain Experience of Black Individuals With Cancer Taking Long-Acting Opioids.Cancer nursingArticle
- Reporting of adverse events for marketed drugs: Need for strengthening safety database.Perspectives in clinical researchReview
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPain is a common symptom in patients with multiple myeloma (MM). Many patients are dependent on analgesics and in particular opioids, but there is limited information on the impact of these drugs and their side effects on health-related quality of life (HRQoL).
methodIn a cross-sectional study, semi-structured interviews were performed in 21 patients attending the hospital with symptomatic MM on pain medications. HRQoL was measured using items 29 and 30 of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30.
resultsPatients were able to recall a median of two (range 0-4) analgesics. They spontaneously identified a median of two (range 1-5) side effects attributable to their analgesic medications. Patients' assessment of HRQoL based on the EORTC QLQ-C30 questions 29/30 was mean 48.3 (95 % CI; 38.7-57.9) out of 100. Patients' assessment of their HRQoL in the hypothetical situation, in which they would not experience any side effects from analgesics, was significantly higher: 62.6 (53.5-71.7) (t test, p = 0.001).
conclusionThis study provides, for the first time, evidence that side effects of analgesics are common in symptomatic MM and may result in a statistically and clinically significant reduction of self-reported HRQoL.
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