ArticleBMC biology2014
Nutrient-responsive regulation determines biodiversity in a colicin-mediated bacterial community.
Article in BMC biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Nutrients and flow shape the cyclic dominance games betweenPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
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- Microcins reveal natural mechanisms of bacterial manipulation to inform therapeutic development.Microbiology (Reading, England) · 2022Article
- Antibacterial Activity of Bacteriocinogenic CommensalAntibiotics (Basel, Switzerland) · 2020Article
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- Bacteria-in-paper, a versatile platform to study bacterial ecology.Ecology letters · 2019Article
- Machine-assisted cultivation and analysis of biofilms.Scientific reports · 2019Article
- Do Organic Substrates Drive Microbial Community Interactions in Arctic Snow?Frontiers in microbiology · 2019Article
- Spatially Correlated Gene Expression in Bacterial Groups: The Role of Lineage History, Spatial Gradients, and Cell-Cell Interactions.Cell systems · 2018Article
- Diversity and distribution of nuclease bacteriocins in bacterial genomes revealed using Hidden Markov Models.PLoS computational biology · 2017Article
- Bet-hedging in bacteriocin producing Escherichia coli populations: the single cell perspective.Scientific reports · 2017Article
- Density-dependent adaptive resistance allows swimming bacteria to colonize an antibiotic gradient.The ISME journal · 2016Article
- The idiosyncrasy of spatial structure in bacterial competition.BMC research notes · 2015Article
- Silencing of DNase Colicin E8 Gene Expression by a Complex Nucleoprotein Assembly Ensures Timely Colicin Induction.PLoS genetics · 2015Article
- Microbial activities and intestinal homeostasis: A delicate balance between health and disease.Cellular and molecular gastroenterology and hepatology · 2015Article
- Reporters for Single-Cell Analysis of Colicin Ib Expression in Salmonella enterica Serovar Typhimurium.PloS one · 2015Article
- Theoretical analysis of the cost of antagonistic activity for aquatic bacteria in oligotrophic environments.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundAntagonistic interactions mediated by antibiotics are strong drivers of bacterial community dynamics which shape biodiversity. Colicin production by Escherichia coli is such an interaction that governs intraspecific competition and is involved in promoting biodiversity. It is unknown how environmental cues affect regulation of the colicin operon and thus influence antibiotic-mediated community dynamics.
resultsHere, we investigate the community dynamics of colicin-producing, -sensitive, and -resistant/non-producer E. coli strains that colonize a microfabricated spatially-structured habitat. Nutrients are found to strongly influence community dynamics: when growing on amino acids and peptides, colicin-mediated competition is intense and the three strains do not coexist unless spatially separated at large scales (millimeters). Surprisingly, when growing on sugars, colicin-mediated competition is minimal and the three strains coexist at the micrometer scale. Carbon storage regulator A (CsrA) is found to play a key role in translating the type of nutrients into the observed community dynamics by controlling colicin release. We demonstrate that by mitigating lysis, CsrA shapes the community dynamics and determines whether the three strains coexist. Indeed, a mutant producer that is unable to suppress colicin release, causes the collapse of biodiversity in media that would otherwise support co-localized growth of the three strains.
conclusionsOur results show how the environmental regulation of an antagonistic trait shapes community dynamics. We demonstrate that nutrient-responsive regulation of colicin release by CsrA, determines whether colicin producer, resistant non-producer, and sensitive strains coexist at small spatial scales, or whether the sensitive strain is eradicated. This study highlights how molecular-level regulatory mechanisms that govern interference competition give rise to community-level biodiversity patterns.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.