ArticleAmerican journal of physiology. Endocrinology and metabolism2014
Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction.
Article in American journal of physiology. Endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Changes in muscle strength and moderators of protein turnover in a rodent model of anorexia nervosa and recovery.bioRxiv : the preprint server for biology · 2025Article
- Unilateral isometric contraction induces REDD1 and suppresses insulin-stimulated mTORC1 and protein synthesis in non-contracted muscle of male mice.Physiological reports · 2025Article
- Unilateral electrical stimulation of mice induces transcriptional response in stimulated leg with limited effect on non-stimulated contralateral leg.Experimental physiology · 2025Article
- Skeletal Muscle-Specific Deletion of E3 Ligase Asb2 Enhances Muscle Mass and Strength.Journal of cachexia, sarcopenia and muscle · 2025Article
- Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.Physiological reviews · 2023Review
- The stress-responsive protein REDD1 and its pathophysiological functions.Experimental & molecular medicine · 2023Review
- The duration of glucocorticoid treatment alters the anabolic response to high-force muscle contractions.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Exercise reduces the protein abundance of TXNIP and its interacting partner REDD1 in skeletal muscle: potential role for a PKA-mediated mechanism.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- A clinically relevant decrease in contractile force differentially regulates control of glucocorticoid receptor translocation in mouse skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Article
- Development and progression of cancer cachexia: Perspectives from bench to bedside.Sports medicine and health science · 2020Article
- A time course for markers of protein synthesis and degradation with hindlimb unloading and the accompanying anabolic resistance to refeeding.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Type 2 diabetes causes skeletal muscle atrophy but does not impair resistance training-mediated myonuclear accretion and muscle mass gain in rats.Experimental physiology · 2019Article
- The role of raptor in the mechanical load-induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- RNA processing in skeletal muscle biology and disease.Transcription · 2019Review
- Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb.Physiological reports · 2018Article
- Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress.BMC biology · 2018Article
- High-intensity eccentric training ameliorates muscle wasting in colon 26 tumor-bearing mice.PloS one · 2018Article
- REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise.American journal of physiology. Endocrinology and metabolism · 2017Article
- Depression of leukocyte protein synthesis, immune function and growth performance induced by high environmental temperature in broiler chickens.International journal of biometeorology · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Regulated in DNA damage and development 1 (REDD1) is a repressor of mTOR complex 1 (mTORC1) signaling. In humans, REDD1 mRNA expression in skeletal muscle is repressed following resistance exercise in association with activation of mTORC1. However, whether REDD1 protein expression is also reduced after exercise and if so to what extent the loss contributes to exercise-induced activation of mTORC1 is unknown. Thus, the purpose of the present study was to examine the role of REDD1 in governing the response of mTORC1 and protein synthesis to a single bout of muscle contractions. Eccentric contractions of the tibialis anterior were elicited via electrical stimulation of the sciatic nerve in male mice in either the fasted or fed state or in fasted wild-type or REDD1-null mice. Four hours postcontractions, mTORC1 signaling and protein synthesis were elevated in fasted mice in association with repressed REDD1 expression relative to nonstimulated controls. Feeding coupled with contractions further elevated mTORC1 signaling, whereas REDD1 protein expression was repressed compared with either feeding or contractions alone. Basal mTORC1 signaling and protein synthesis were elevated in REDD1-null compared with wild-type mice. The magnitude of the increase in mTORC1 signaling was similar in both wild-type and REDD1-null mice, but, unlike wild-type mice, muscle contractions did not stimulate protein synthesis in mice deficient for REDD1, presumably because basal rates were already elevated. Overall, the data demonstrate that REDD1 expression contributes to the modulation of mTORC1 signaling following feeding- and contraction-induced activation of the pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.