ArticleMedical oncology (Northwood, London, England)2014
Association between CCNE1 polymorphisms and the risk of breast cancer in a sample of southeast Iranian population.
Article in Medical oncology (Northwood, London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Distinct gene expression profiles associated with clinical outcomes in patients with ovarian clear cell carcinoma and high-grade serous ovarian carcinoma.Journal of ovarian research · 2020Article
- CircDENND2A Promotes Non-small Cell Lung Cancer Progression via Regulating MiR-34a/CCNE1 Signaling.Frontiers in genetics · 2020Article
- Genetic and molecular biology of breast cancer among Iranian patients.Journal of translational medicine · 2019Review
- KRAS Gene Polymorphisms and their Impact on Breast Cancer Risk in an Iranian PopulationAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Article
- Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk.Biomedical reports · 2016Article
- APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population.International journal of molecular and cellular medicine · 2015Article
- Association between hTERT polymorphisms and the risk of breast cancer in a sample of Southeast Iranian population.BMC research notes · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclin E1 (CCNE1) is a key proto-oncogene. The present study aimed to investigate the effects of single nucleotide polymorphisms in CCNE1 on the risk of breast cancer (BC) in an Iranian population in southeast of Iran. A total of 491 subjects including 266 BC patients and 225 healthy control women were participated in the study. Genotyping of CCNE1 rs3218073 and 72010703 polymorphisms was done using allele-specific polymerase chain reaction (AS-PCR) and rs1406 by PCR-RFLP method.Our findings showed that rs1406 C/A polymorphism increased the risk of BC in codominant (OR 1.60, 95% CI 1.05-2.43, p=0.032 CA vs CC; OR 2.35, 95% CI 1.23-4.49, p=0.011 AA vs CC) and dominant (OR 1.69, 95% CI 1.22-2.56, p=0.012 CA+AA vs CC) inheritance models. The rs1406 A allele increased the risk of BC (OR 1.37, 95% CI 1.06-1.76, p=0.019) in comparison with C allele. On the other hand, CCNE1 rs72010703 (4-bp I/D) and rs3218073 polymorphisms did not show any significant association with BC. This study indicates that CCNE1 rs1406 polymorphism may contribute to BC risk.
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