ReviewEndocrine2015
A four-season molecule: osteocalcin. Updates in its physiological roles.
Review in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03386981 (Study of the Metabolic Profile of Bone in Professional Athletes as a Function of the Kind of Physical Activity Performed), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Metabolic Profile of Bone in Professional Athletes as a Function of the Kind of Physical Activity Performed
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Bone Biomarker Response to an Acute Bout of Exercise: A Systematic Review with Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Effects of Exercise on Bone Status in Female Subjects, from Young Girls to Postmenopausal Women: An Overview of Systematic Reviews and Meta-Analyses.Sports medicine (Auckland, N.Z.) · 2016Pooled it
- Load carriage aerobic exercise stimulates a transient rise in biochemical markers of bone formation and resorption.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Effect of Vitamin D-Enriched Gouda-Type Cheese Consumption on Biochemical Markers of Bone Metabolism in Postmenopausal Women in Greece.Nutrients · 2021Trial
- Membranes for Bone Engineering Enriched with Magnesium- and Strontium-Substituted Hydroxyapatite.ACS omega · 2026Article
- Variation of bone-related and inflammatory biomarkers after a half-marathon running in trained subjects.European journal of applied physiology · 2025Article
- Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications.ChemistryOpen · 2025Review
- Review
- Bone and muscle crosstalk in ageing and disease.Nature reviews. Endocrinology · 2025Review
- An analysis of vitamin K status in Chinese healthy children aged 0-18 years.BMC pediatrics · 2024Article
- Association between antibiotics use and osteoporotic fracture risk: a nationally representative retrospective cohort study.Archives of osteoporosis · 2024Article
- Low Vitamin K Status in Patients with Psoriasis Vulgaris: A Pilot Study.Biomedicines · 2024Article
- Assessment of Antimicrobial Activity of Nanocomposites Based on Nano-Hydroxyapatite (HAP), Chitosan, and Vitamin K2.Cureus · 2024Article
- The fusion of keratinized epithelium, an indication of early implant placement in the aesthetic area: an animal study.BMC oral health · 2023Article
- The human lens is capable of trilineage differentiation towards osteo-, chondro-, and adipogenesis-a model for studying cataract pathogenesis.Frontiers in bioengineering and biotechnology · 2023Article
- Crosstalk between bone and other organs.Medical review (2021) · 2022Review
- Human Osteochondral Explants as an Ex Vivo Model of Osteoarthritis for the Assessment of a Novel Class of Orthobiologics.Pharmaceutics · 2022Article
- Sleep Disruption and Bone Health.Current osteoporosis reports · 2022Review
- The Effects of Osteoporotic and Non-osteoporotic Medications on Fracture Risk and Bone Mineral Density.Drugs · 2021Review
- Vitamin K-Dependent Proteins in Skeletal Development and Disease.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteocalcin (OC) is the main non-collagenous hydroxyapatite-binding protein synthesized by osteoblasts, odontoblasts, and hypertrophic chondrocytes. It has a regulatory role in mineralization and it is considered a marker of bone cell metabolism. Recent findings evidenced new extra-skeletal roles for OC, depicting it as a real hormone. OC shares many functional features with the common hormones, such as tissue-specific expression, circadian rhythm, and synthesis as a pre-pro-molecule. However, it has some peculiar features making it a unique molecule: OC exists in different forms based on the degree of carboxylation. Indeed, OC has three glutamic acid residues, in position 17, 21, and 24, which are subject to γ-carboxylation, through the action of a vitamin K-dependent γ-glutamyl carboxytransferase. The degree of carboxylation, and thus the negative charge density, determines the affinity for the calcium ions deposited in the extracellular matrix of the bone. The modulation of the carboxylation could, thus, represent the mechanism by which the body controls the circulating levels, and hence the hormonal function, of OC. There are evidences linking OC, and the bone metabolism, with a series of endocrine (glucose metabolism, energy metabolism, fertility) physiological (muscle activity) and pathological functions (ectopic calcification). Aim of this review is to give a full overview of the physiological roles of OC by collecting the newest experimental findings on this intriguing molecule.
Indexed as
Identifiers
25158976What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.